Hybrid Monday Lecture Series
(open to the Rockefeller community)
Monday, September 23, 2024
Luciano Marraffini, Ph.D.
Kayden Family Professor and Head of the Laboratory of Bacteriology, The Rockefeller University; Investigator, Howard Hughes Medical Institute
CRISPR-CARF Immunity: Sacrificing the Host for the Benefit of the Population
Recommended Readings:
Baca, Christian F., et al. “The CRISPR effector Cam1 mediates membrane depolarization for phage defence.” Nature 625.7996 (2024): 797-804.
Rostøl, Jakob T., et al. “The Card1 nuclease provides defence during type III CRISPR immunity.” Nature 590.7847 (2021): 624-629.
McMahon, Stephen A., et al. “Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate.” Nature communications 11.1 (2020): 500.
Garneau, Josiane E., et al. “The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA.” Nature 468.7320 (2010): 67-71.
Barrangou, Rodolphe, et al. “CRISPR provides acquired resistance against viruses in prokaryotes.” Science 315.5819 (2007): 1709-1712.
