Hybrid Friday Lecture Series
(open to the Rockefeller and Tri-Institutional communities)
Friday, January 19, 2024
David Liu, Ph.D.
Professor of Chemistry and Chemical Biology, Harvard University; Investigator, Howard Hughes Medical Institute; Associate Faculty Member, Harvard Microbial Sciences Initiative; Core Institute Member and Vice-Chair of the Faculty, Broad Institute of Harvard and MIT; Director, Chemical Biology and Therapeutics Science (CBTS) Program at the Broad Institute; Richard Merkin Professor and Director of the Merkin Institute of Transformative Technologies in Healthcare at the Broad Institute of Harvard and MIT; Thomas Dudley Cabot Professor of the Natural Sciences, Harvard University
Base Editing and Prime Editing: Engineered Proteins that Precisely Correct Pathogenic Mutations in Cells, Animals, and Patients
Recommended Readings:
Arbab, Mandana, et al. “Base editing rescue of spinal muscular atrophy in cells and in mice.” Science 380.6642 (2023): eadg6518.
Banskota, Samagya, et al. “Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins.” Cell 185.2 (2022): 250-265.
Chen, Peter J., et al. “Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.” Cell 184.22 (2021): 5635-5652.
Newby, Gregory A., et al. “Base editing of haematopoietic stem cells rescues sickle cell disease in mice.” Nature 595.7866 (2021): 295-302.
Blum, Travis R., et al. “Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity.” Science 371.6531 (2021): 803-810.
