Hybrid Friday Lecture Series
(open to the Rockefeller and Tri-Institutional communities)
Friday, October 27, 2023
Adrian R. Krainer, Ph.D.
St. Giles Foundation Professor, Cancer Center Deputy Director of Research;
Cold Spring Harbor Laboratory
Antisense Therapies for Spinal Muscular Atrophy and Diffuse Midline Glioma
Recommended Readings:
Empirical Articles
Zhang, Qian, et al. “Antisense oligonucleotide therapy for H3. 3K27M diffuse midline glioma.” Science Translational Medicine 15.691 (2023): eadd8280.
Barranco, Caroline. “Promising results for antisense RNA therapy in mouse models of diffuse midline glioma.” Nature Reviews Neurology (2023): 1-1.
Marasco, Luciano E., et al. “Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy.” Cell 185.12 (2022): 2057-2070.
Rahman, Mohammad Alinoor, Adrian R. Krainer, and Omar Abdel-Wahab. “SnapShot: splicing alterations in cancer.” Cell 180.1 (2020): 208-208.
Nomakuchi, Tomoki T., et al. “Antisense oligonucleotide–directed inhibition of nonsense-mediated mRNA decay.” Nature Biotechnology 34.2 (2016): 164-166.
