Friday Lecture Series
(open to the Rockefeller community)
Friday, April 29, 2022
Hans Clevers, M.D., Ph.D.
Professor of Molecular Genetics,
University Utrecht
Head of Pharma, Research and Early Development (pRED)
Member of the Enlarged Executive Committee
F. Hoffmann-La Roche Ltd
Organoids to Model Human Disease
Recommended Readings:
Empirical Articles
Kim, J., Koo, B. K., & Clevers, H. (2022). Organoid Studies in COVID-19 Research. International journal of stem cells, 15(1), 3–13.
van der Vaart, J., Bosmans, L., Sijbesma, S. F., Knoops, K., van de Wetering, W. J., Otten, H. G., Begthel, H., Borel Rinkes, I., Korving, J., Lentjes, E., Lopez-Iglesias, C., Peters, P. J., van Santen, H. M., Vriens, M. R., & Clevers, H. (2021). Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves’ hyperthyroidism. Proceedings of the National Academy of Sciences of the United States of America, 118(51), e2117017118.
Giobbe, G. G., Bonfante, F., Jones, B. C., Gagliano, O., Luni, C., Zambaiti, E., Perin, S., Laterza, C., Busslinger, G., Stuart, H., Pagliari, M., Bortolami, A., Mazzetto, E., Manfredi, A., Colantuono, C., Di Filippo, L., Pellegata, A. F., Panzarin, V., Thapar, N., Li, V., Eaton, S, Cacchiarelli, D, Clevers, H., Elvassore, N., & De Coppi, P. (2021). SARS-CoV-2 infection and replication in human gastric organoids. Nature communications, 12(1), 6610.
van der Vaart, J., Böttinger, L., Geurts, M. H., van de Wetering, W. J., Knoops, K., Sachs, N., Begthel, H., Korving, J., Lopez-Iglesias, C., Peters, P. J., Eitan, K., Gileles-Hillel, A., & Clevers, H. (2021). Modelling of primary ciliary dyskinesia using patient-derived airway organoids. EMBO reports, 22(12), e52058.
Beumer, J., Geurts, M. H., Lamers, M. M., Puschhof, J., Zhang, J., van der Vaart, J., Mykytyn, A. Z., Breugem, T. I., Riesebosch, S., Schipper, D., van den Doel, P. B., de Lau, W., Pleguezuelos-Manzano, C., Busslinger, G., Haagmans, B. L., & Clevers, H. (2021). A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses. Nature communications, 12(1), 5498.
