Recommended Readings: Thomas P. Sakmar, M.D., March 21th, 2022

Recommended Readings: Thomas P. Sakmar, M.D., March 21th, 2022

Monday Lecture Series

(open to the Rockefeller community)

Monday, March 21, 2022

Thomas P. Sakmar, M.D.

Richard M. & Isabel P. Furlaud Professor,
Senior Physician, Rockefeller University Hospital,
Director, Human Subjects Research Protection Program,
Head of Laboratory of Chemical Biology & Signal Transduction
The Rockefeller University


Activity Profiling of Genetic Variants of the CYSLTR2 Oncogene Responsible for Uveal Melanoma

Recommended Readings:

Empirical Articles

Ceraudo, E., Horioka, M., Mattheisen, J. M., Hitchman, T. D., Moore, A. R., Kazmi, M. A., Chi, P., Chen, Y., Sakmar, T. P., & Huber, T. (2021). Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling. The Journal of biological chemistry, 296, 100163.

Hitchman, T. D., Bayshtok, G., Ceraudo, E., Moore, A. R., Lee, C., Jia, R., Wang, N., Pachai, M. R., Shoushtari, A. N., Francis, J. H., Guan, Y., Chen, J., Chang, M. T., Taylor, B. S., Sakmar, T. P., Huber, T., Chi, P., & Chen, Y. (2021). Combined Inhibition of Gαq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma. Clinical cancer research, 27(5), 1476–1490.

Horioka, M., Huber, T., & Sakmar, T. P. (2020). Playing Tag with Your Favorite GPCR Using CRISPR. Cell chemical biology, 27(6), 642–644.

Lorenzen, E., Dodig-Crnković, T., Kotliar, I. B., Pin, E., Ceraudo, E., Vaughan, R. D., Uhlèn, M., Huber, T., Schwenk, J. M., & Sakmar, T. P. (2019). Multiplexed analysis of the secretin-like GPCR-RAMP interactome. Science advances, 5(9), eaaw2778.

Barbash, S., Persson, T., Lorenzen, E., Kazmi, M. A., Huber, T., & Sakmar, T. P. (2019). Detection of Concordance between Transcriptional Levels of GPCRs and Receptor-Activity-Modifying Proteins. iScience, 11, 366–374.

By |2022-03-01T19:31:06+00:00March 1st, 2022|Categories: Chemical Biology, Genetics, Monday Lectures|Tags: , , |Comments Off on Recommended Readings: Thomas P. Sakmar, M.D., March 21th, 2022

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