Monday Lecture Series
(open to the Rockefeller community)
Monday, March 21, 2022
Thomas P. Sakmar, M.D.
Richard M. & Isabel P. Furlaud Professor,
Senior Physician, Rockefeller University Hospital,
Director, Human Subjects Research Protection Program,
Head of Laboratory of Chemical Biology & Signal Transduction
The Rockefeller University
Activity Profiling of Genetic Variants of the CYSLTR2 Oncogene Responsible for Uveal Melanoma
Recommended Readings:
Empirical Articles
Ceraudo, E., Horioka, M., Mattheisen, J. M., Hitchman, T. D., Moore, A. R., Kazmi, M. A., Chi, P., Chen, Y., Sakmar, T. P., & Huber, T. (2021). Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling. The Journal of biological chemistry, 296, 100163.
Hitchman, T. D., Bayshtok, G., Ceraudo, E., Moore, A. R., Lee, C., Jia, R., Wang, N., Pachai, M. R., Shoushtari, A. N., Francis, J. H., Guan, Y., Chen, J., Chang, M. T., Taylor, B. S., Sakmar, T. P., Huber, T., Chi, P., & Chen, Y. (2021). Combined Inhibition of Gαq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma. Clinical cancer research, 27(5), 1476–1490.
Horioka, M., Huber, T., & Sakmar, T. P. (2020). Playing Tag with Your Favorite GPCR Using CRISPR. Cell chemical biology, 27(6), 642–644.
Lorenzen, E., Dodig-Crnković, T., Kotliar, I. B., Pin, E., Ceraudo, E., Vaughan, R. D., Uhlèn, M., Huber, T., Schwenk, J. M., & Sakmar, T. P. (2019). Multiplexed analysis of the secretin-like GPCR-RAMP interactome. Science advances, 5(9), eaaw2778.
Barbash, S., Persson, T., Lorenzen, E., Kazmi, M. A., Huber, T., & Sakmar, T. P. (2019). Detection of Concordance between Transcriptional Levels of GPCRs and Receptor-Activity-Modifying Proteins. iScience, 11, 366–374.
