Monday Lecture Series
Monday, November 30, 2015
4:00 p.m., Carson Family Auditorium (CRC)
David C. Gadsby, Ph.D.
Patrick A. Gerschel Family Professor and Head
Laboratory of Cardiac and Membrane Physiology,
The Rockefeller University
Motions that gate single CFTR channels, the ABC proteins whose failure causes cystic fibrosis
Recommended Readings
Chaves, L. A. P., & Gadsby, D. C. (2015). Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels. The Journal of General Physiology, 145(4), 261-283. doi:10.1085/jgp.201411347
Csanády, L., Vergani, P., & Gadsby, D. C. (2010). Strict coupling between CFTR’s catalytic cycle and gating of its Cl− ion pore revealed by distributions of open channel burst durations. Proceedings of the National Academy of Sciences, 107(3), 1241-1246. doi:10.1073/pnas.0911061107
Gadsby, D. C., Vergani, P., & Csanády, L. (2006). The ABC protein turned chloride channel whose failure causes cystic fibrosis. Nature, 440(7083), 477-483. doi:10.1038/nature04712
Vergani, P., Lockless, S. W., Nairn, A. C., & Gadsby, D. C. (2005). CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains. Nature, 433(7028), 876-880. doi:10.1038/nature03313
