Friday Lecture Series
(open to the Rockefeller and Tri-Institutional communities)
Friday, May 9, 2025
Nada Jabado, M.D., Ph.D.
Pediatric Neuro-oncologist, Montreal Children’s Hospital; Professor of Pediatrics, McGill University
Histone 3 Mutations in Disease: “Every Amino Acid Matters”
The Cancer Biology Lecture
Recommended Readings:
Andrade, Augusto Faria, et al. “Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function.” Nature Communications 15.1 (2024): 7769.
Andrade, Augusto Faria, Carol CL Chen, and Nada Jabado. “Oncohistones in brain tumors: the soil and seed.” Trends in cancer 9.5 (2023): 444-455.
Deshmukh, Shriya, et al. “Oncohistones: a roadmap to stalled development.” The FEBS journal 289.5 (2022): 1315-1328.
Chaouch, Amel, et al. “Histone H3. 3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks.” Molecular cell 81.23 (2021): 4876-4890.
Chen, Carol CL, et al. “Histone H3. 3G34-mutant interneuron progenitors co-opt PDGFRA for gliomagenesis.” Cell 183.6 (2020): 1617-1633.
