Friday Lecture Series
(open to the Rockefeller and Tri-Institutional communities)
Friday, May 2, 2025
Vishva Dixit, M.D.
Vice President and Senior Fellow, Physiological Chemistry, Research Biology, Genentech
Why So Many Ways To Die?
The Maclyn McCarty Memorial Lecture
Recommended Readings:
Pourmal, Sergei, et al. “Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture.” Nature 637.8045 (2025): 446-452.
Kayagaki, Nobuhiko, et al. “Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury.” Nature 618.7967 (2023): 1072-1077.
Kayagaki, Nobuhiko, et al. “NINJ1 mediates plasma membrane rupture during lytic cell death.” Nature 591.7848 (2021): 131-136.
Kayagaki, Nobuhiko, et al. “Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.” Nature 526.7575 (2015): 666-671.
Kayagaki, Nobuhiko, et al. “Noncanonical inflammasome activation by intracellular LPS independent of TLR4.” Science 341.6151 (2013): 1246-1249.
Kayagaki, Nobuhiko, et al. “Non-canonical inflammasome activation targets caspase-11.” Nature 479.7371 (2011): 117-121.
