Hybrid Monday Lecture Series
(open to the Rockefeller community)
Monday, March 10, 2025
Tarun Kapoor, Ph.D.
Pels Family Professor and Head of the Selma and Lawrence Ruben Laboratory of Chemistry and Cell Biology, The Rockefeller University
Chemical Activators of VCP, an Unfoldase Required for Proteostasis
Recommended Readings:
Jones, Natalie H., et al. “Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry.” Proceedings of the National Academy of Sciences 121.24 (2024): e2316892121.
Vostal, Lauren E., et al. “Distinct modes of coupling between VCP, an essential unfoldase, and deubiquitinases.” bioRxiv (2024): 2024-09.
Huryn, Donna M., David JP Kornfilt, and Peter Wipf. “p97: an emerging target for cancer, neurodegenerative diseases, and viral infections.” Journal of medicinal chemistry 63.5 (2019): 1892-1907.
Seraphim, Thiago V., and Walid A. Houry. “AAA+ proteins.” Current Biology 30.6 (2020): R251-R257.
Puchades, Cristina, Colby R. Sandate, and Gabriel C. Lander. “The molecular principles governing the activity and functional diversity of AAA+ proteins.” Nature Reviews Molecular Cell Biology 21.1 (2020): 43-58.
