Chemical & Structural Biology Seminar Series
(open to the Rockefeller and Tri-Institutional communities)
Friday, April 1, 2025
Chaitan Khosla, Ph.D.
Wells H. Rauser and Harold M. Petiprin Professor and Professor of Chemistry and Biochemistry, Department of Chemical Engineering, Stanford University
Chemical Biology-Led Unraveling of the TG2/LRP1 Pathway for Antigen Presentation in Celiac Disease
Recommended Readings:
Meling, Maureen T., et al. “Enterocyte-derived and catalytically active transglutaminase 2 in the gut lumen of mice: Implications for celiac disease.” Gastroenterology (2024).
Iversen, Rasmus, and Ludvig M. Sollid. “The immunobiology and pathogenesis of celiac disease.” Annual Review of Pathology: Mechanisms of Disease 18.1 (2023): 47-70.
Loppinet, Elise, et al. “Targeted lysosomal degradation of secreted and cell surface proteins through the LRP-1 pathway.” Journal of the American Chemical Society 145.34 (2023): 18705-18710.
Besser, Harrison A., and Chaitan Khosla. “Celiac disease: mechanisms and emerging therapeutics.” Trends in Pharmacological Sciences 44.12 (2023): 949-962.
Iversen, Rasmus, et al. “Evidence that pathogenic transglutaminase 2 in celiac disease derives from enterocytes.” Gastroenterology 159.2 (2020): 788-790.
