Hybrid Monday Lecture Series
(open to the Rockefeller community)
Monday, October 28, 2024
Michael O’Donnell, Ph.D.
Anthony and Judith Evnin Professor and Head of the Laboratory of DNA Replication, The Rockefeller University; Investigator, Howard Hughes Medical Institute
Mechanism and Structure of the 4 Eukaryotic Clamp Loaders
Recommended Readings:
Yuan, Zuanning, et al. “Mechanism of PCNA loading by Ctf18-RFC for leading-strand DNA synthesis.” Science 385.6708 (2024): eadk5901.
Wang, Feng, et al. “The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader.” Nature Structural & Molecular Biology (2024): 1-12.
Li, Huilin, Mike O’Donnell, and Brian Kelch. “Unexpected new insights into DNA clamp loaders: Eukaryotic clamp loaders contain a second DNA site for recessed 5′ ends that facilitates repair and signals DNA damage.” Bioessays 44.11 (2022): 2200154.
Hedglin, Mark, Ravindra Kumar, and Stephen J. Benkovic. “Replication clamps and clamp loaders.” Cold Spring Harbor perspectives in biology 5.4 (2013): a010165.
Yao, Nina Y., and Mike O’Donnell. “The RFC clamp loader: structure and function.” The Eukaryotic Replisome: A Guide to Protein Structure and Function (2012): 259-279.
