Recommended Readings: Howard C. Hang, Ph.D. Friday October 19, 2018

Friday Lectures

Friday, October 19, 2018  3:45 p.m.

Caspary Auditorium

Howard C. Hang Ph.D.

Richard E. Salomon Family Associate Professor and Head

Laboratory of Chemical Biology and Microbial Pathogenesis

The Rockefeller University

Chemical Dissection of Host-Microbe Interactions

Recommended Readings:

Empirical Articles

Liu W, Zhou Y, Peng T, Zhou P, Ding X, Li Z, Zhong H, Xu Y, Chen S, Hang HC, Shao F. (2018). Nε-fatty acylation of multiple membrane-associated proteins by Shigella IcsB effector to modulate host function. NATURE MICROBIOLOGY. 3 (9): 996-1009

Thinon, Emmanuelle; Fernandez, Joseph P.; Molina, Henrik; et al. (2018). Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites. JOURNAL OF PROTEOME RESEARCH. 17 (5): 1907-1922

Westcott N, Fernandez JP, Molina H, Hang HC. (2017). Chemical proteomics reveals ADP-ribosylation of small GTPases during oxidative stress. NATURE CHEMICAL BIOLOGY. 13 (3): 302-308

Peng T, Hang HC. (2016). Site-Specific Bioorthogonal Labeling for Fluorescence Imaging of Intracellular Proteins in Living Cells. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 138 (43): 14423-14433

Rangan, Kavita J.; Pedicord, Virginia A.; Wang, Yen-Chih; et al. (2016). A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens. SCIENCE. 353 (6306): 1434-1437

Percher, Avital; Ramakrishnan, Srinivasan; Thinon, Emmanuelle; et al. (2016). Mass-tag labeling reveals site-specific and endogenous levels of protein S-fatty acylation. PNAS. 113 (16): 4302-7

Review Paper

Peng, Tao; Thinon, Emmanuelle; Hang, Howard C. (2016). Proteomic analysis of fatty-acylated proteins. CURRENT OPINION IN CHEMICAL BIOLOGY. 30: 77-86

Westcott, Nathan P.; Hang, Howard C. (2014). Chemical reporters for exploring ADP-ribosylation and AMPylation at the host-pathogen interface.  CURRENT OPINION IN CHEMICAL BIOLOGY. 23: 56-62

Grammel, Markus; Hang, Howard C. (2013). Chemical reporters for biological discovery. NATURE CHEMICAL BIOLOGY. 9 (8): 475-484

Recommended Readings: Titia de Lange, Ph.D., Monday October 15, 2018

Monday Lectures

Monday, October 15, 2018  4:00 p.m.

Carson Family Auditorium

Titia de Lange, Ph.D.

Leon Hess Professor and Head

Laboratory of Cell Biology and Genetics

The Rockefeller University


Understanding DSB Repair: How Telomeres Gave Us a Break(through)


Recommended Readings:

Science News

Scientists discover a mechanism of drug resistance in breast and ovarian cancer. July 18, 2018. ScienceDaily 

Empirical Articles

Mirman Z, Lottersberger F, Takai H, Kibe T. et al. (2018). 53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. NATURE. 560 (7716): 112-116

Gong, Yi; Handa, Naofumi; Kowalczykowski, Stephen C.; et al. (2017). PHF11 promotes DSB resection, ATR signaling, and HR. GENES AND DEVELOPMENT. 31 (1): 46-58

Doksani, Ylli; de Lange, Titia. (2016). Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining. CELL REPORTS. 17 (6)1646-1656

Lottersberger, Francisca; Karssemeijer, Roos Anna; Dimitrova, Nadya; et al. (2015). 53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair. CELL. 163 (4):  880-893 

Doksani Y, de Lange T. (2014). The role of double-strand break repair pathways at functional and dysfunctional telomeres. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 6 (12)

Zimmermann, Michal; Lottersberger, Francisca; Buonomo, Sara B.; et al. (2013). 53BP1 Regulates DSB Repair Using Rif1 to Control 5 ‘ End Resection. SCIENCE. 339 (6120): 700-704

Lottersberger, Francisca; Bothmer, Anne; Robbiani, Davide F.; et al. (2013). Role of 53BP1 oligomerization in regulating double-strand break repair. PNAS. 110 (6): 2146-2151

Review Papers

Maciejowski, John; de lange, Titia. (2017). Telomeres in cancer: tumour suppression and genome instability. NATURE REVIEWS MOLECULAR CELL BIOLOGY. 18 (3): 175-186

Zimmerman, Michal; de Lange, Titia. (2014). 53BP1: pro choice in DNA repair. TRENDS IN CELL BIOLOGY. 24 (2)108-117