Recommended Readings: Wei Yang, Ph.D. March 10

Monday, March 10, 2014
4:00 p.m., Carson Family Auditorium

Wei Yang, Ph.D.
Senior Investigator and Section Chief
Department of Molecular Biology
National Institute of Diabetes and Digestive and Kidney Diseases
National Institutes of Health

Human DNA polymerase η: from Chemistry to Cancer Biology

Recommended Readings:

Empirical Articles

Biertümpfel, C., Zhao, Y., Kondo, Y., Ramón-Maiques, S., Gregory, M., Lee, J. Y., … Yang, W. (2010). Structure and mechanism of human DNA polymerase η. Nature, 465(7301), 1044–1048. doi:10.1038/nature09196

Nakamura, T., Zhao, Y., Yamagata, Y., Hua, Y., & Yang, W. (2012). Watching DNA polymerase η make a phosphodiester bond. Nature, 487(7406), 196–201. doi:10.1038/nature11181

Zhao, Y., Biertümpfel, C., Gregory, M. T., Hua, Y.-J., Hanaoka, F., & Yang, W. (2012). Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin. Proceedings of the National Academy of Sciences of the United States of America, 109(19), 7269–7274. doi:10.1073/pnas.1202681109

Zhao, Y., Gregory, M. T., Biertümpfel, C., Hua, Y., Hanaoka, F., & Yang, W. (2013). Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η. Proceedings of the National Academy of Sciences of the United States of America, 110(20), 8146–8151. doi:10.1073/pnas.1303126110

Review Papers

Lange, S. S., Takata, K., & Wood, R. D. (2011). DNA polymerases and cancer. Nature Reviews Cancer, 11(2), 96–110. doi:10.1038/nrc2998

Sale, J. E., Lehmann, A. R., & Woodgate, R. (2012). Y-family DNA polymerases and their role in tolerance of cellular DNA damage. Nature Reviews Molecular Cell Biology, 13(3), 141–152. doi:10.1038/nrm3289

Yang, W. (2003). Damage repair DNA polymerases Y. Current Opinion in Structural Biology, 13(1), 23–30. doi:10.1016/S0959-440X(02)00003-9