Vitamin D Receptor Binding Sites Identified

NEW YORK (GenomeWeb News) – Vitamin D seems to influence the activity of scores of genes across the genome and may influence some genes implicated in some human diseases, including some autoimmune conditions and cancers, according to a new study in which researchers mapped vitamin D receptor binding sites across the genome and gauged vitamin D-related expression patterns.

An international research team led by investigators at the Wellcome Trust Centre for Human Genetics used chromatin immunoprecipitation coupled with massively parallel sequencing to find nearly 3,000 vitamin D receptor binding sites in cells treated with active vitamin D. Many of these sites seemed to cluster near genes linked to human diseases and other traits through past genome-wide association studies, they noted.  The study appears in Genome Research.