Recommended Readings: Christer Betsholtz, Ph.D.

Friday Lecture Series

It Takes Two to Make a Blood Vessel: Endothelial/Pericyte Interactions in Angiogenesis and Vascular Permeability

Christer Betsholtz, Ph.D., professor of vascular biology,

The Karolinska Institute

October 26, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Armulik, A., G. Genové, and C. Betsholtz. 2011. “Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises.” Developmental Cell 21 (2): 193-215

Armulik, A., G. Genové, M. Mäe, M. H. Nisancioglu, E. Wallgard, C. Niaudet, L. He, et al. 2010. “Pericytes Regulate the Blood-Brain Barrier.” Nature 468 (7323): 557-561

Bell, R. D., E. A. Winkler, I. Singh, A. P. Sagare, R. Deane, Z. Wu, D. M. Holtzman, et al. 2012. “Apolipoprotein e Controls Cerebrovascular Integrity Via Cyclophilin A.” Nature 485 (7399): 512-516

Gaengel, K., G. Genové, A. Armulik, and C. Betsholtz. 2009. “Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis.” Arteriosclerosis, Thrombosis, and Vascular Biology 29 (5): 630-638

Rymo, S. F., H. Gerhardt, F. W. Sand, R. Lang, A. Uv, and C. Betsholtz. 2011. “A Two-Way Communication between Microglial Cells and Angiogenic Sprouts Regulates Angiogenesis in Aortic Ring Cultures.” PLoS ONE 6 (1)

Tammela, T., G. Zarkada, E. Wallgard, A. Murtomäki, S. Suchting, M. Wirzenius, M. Waltari, et al. 2008. “Blocking VEGFR-3 Suppresses Angiogenic Sprouting and Vascular Network Formation.” Nature 454 (7204): 656-660


New Blood-vessel-generating Stem Cell with Therapeutic Potential

Researchers at the University of Helsinki, Finland, believe they have discovered stem cells that play a decisive role in new blood vessel growth. If researchers learn to isolate and efficiently produce these stem cells found in blood vessel walls, the cells offer new opportunities in the treatment of cardiovascular diseases, cancer and many other diseases. The study is published in the PLOS Biology journal on 16 October 2012.