Recommended Readings: Lingyin Li, Ph.D., February 25

Special Lecture
Wednesday, February 25, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Lingyin Li, Ph.D.,
Merck Fellow of the Jane Coffins Child Memorial Fund,
Department of Systems Biology,
Harvard Medical School

Chemical Biology of Anti-Cancer Innate Immunity

Recommended Readings

Kim, S., Li, L., Maliga, Z., Yin, Q., Wu, H., & Mitchison, T. J. (2013). Anticancer flavonoids are mouse-selective STING agonists. ACS Chemical Biology, 8(7), 1396–1401. doi:10.1021/cb400264n

Li, L., Yin, Q., Kuss, P., Maliga, Z., Wu, H., & Mitchison, T. J. (2014). Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nature Chemical Biology, 10(12), 1043–1048. doi:10.1038/nchembio.1661

Critical Review: The Origin of Cancer Robustness and Evolvability

This article, one of the most highly viewed and downloaded articles among Royal Society publications  in the past month, challenges our approaches to cancer which have failed to achieved expected improvements in dieases outcomes.   The authors suggest that a better understanding of underlying tumor robustness might lead to more successful research directions.

Related Readings – Mikala Egeblad Ph.D.

Seeing Tumors in Context:

New Insights into the Dynamics of the Tumor Microenvironment

Monday, March 24, 2008

Welch Hall    Markus Library Level Two    4 p.m.     Refreshments at 3:45 p.m.

Recommended Review Article:

Bissell, M. J. and D. Radisky (2001). Putting tumors in context.  Nature Reviews Cancer. 1(1): 46-54


Related Articles:

Kouros-Mehr, H; S. K. Bechis and E. M. Slorach et al.  (2008). GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell. 13(2): 141-152

Maata, J.A.; M. Sundivall; T.T. Junttila et al.   (2006). Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth.  Molecular Biology of the Cell. 17(1):67-79

Littlepage, L.E. and M. Egeblad.  (2005). Coevolution of cancer and stromal cellular responses. Cancer Cell.  7(6):499-500

Li, Y; B. Welm; and K. Podsypanina. (2003). Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.  PNAS. 100(26):15853-15858