Recommended Readings: Hani S. Zaher, PH.D. Monday, March 5, 2012

Dealing with Mistakes: a New Form of Proofreading on the Ribosome

Hani S. Zaher, Ph.D

Postdoctoral Fellow

Department of Molecular Biology and Genetics

Johns Hopkins School of Medicine

4:00 p.m.  Monday, March 5, 2012   Refreshments at 3:45

Caspary Auditorium

Recommended Readings:

Zaher HS; Shaw JJ; Strobel SA; et al.  2011.  The 2’-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTCEMBO Journal.   30(12):2445-2453.   DOI:10.1038/emboj.2011.142

Zaher HS; Green R.  2011.  A primary role for release factor 3 in quality control during translation eloncation in Escherichia coli.  CELL.  147(2):396-408.   DOI:10.1016/j.cell.2011.08.45

Zaher HS; Green R.  2010.  Kinetic basis for global loss of fidelity arising from mismatches in the P-site codon:anticodon helix.   RNA-A Publication of the RNA Society.  16(10):1980-1989.  DOI:10.1261/rna.2241810.

Zaher HS; Green R.  2010.  Hyperaccurate and error-prone ribosomes exploit distinct mechanisms during tRFNA selectionMolecular Cell   39(1):110-120.   DOI:10.1016/j.molcel.2010.06.009

Zaher HS; Green R. 2009.  Fidelity at the molecular level: lessons from protein synthesis.   CELL.  136(4):746-762.  DOI:10.1016/j.cell.2009.01.036

Zaher HS; Green R.  2009.  Quality control by the ribosome following peptide bond formation.  NATURE.  457(7226):161-U51.   DOI:10.1038/nature07582

Structural Biology Lecture Series: Venki Ramakrishnan Ph.D. Wed Sept 28 2011

Structural Biology Lecture Series

The Structural Basis of Decoding by the Ribosome

Dr. Venki Ramakrishnan

2009 Nobelist

Medical Research Council Laboratory of Molecular Biology

Wednesday September 28, 11 am, Caspary Hall

Recommended Readings:

Voorhees RM; Schmeing TM; Kelley AC; Ramakrishnan V. 2010. The mechanism for activation of GTP hydrolysis on the ribosome. Science 330:835-838.

Schmeing TM; Voorhees RM; Kelley AC; et al.  2009. The crystal structure of the ribosome bound to EF-Tu and aminoacyl-tRNA.  Science  326(5953):688-694.

Gao Y-G; Selmer M; Dunham CM; Weixlbaumer A; Kelley AC; Ramakrishnan V. 2009. The structure of the ribosome with elongation factor G trapped in the posttranslocational state. Science 326:694-699.

Weixlbaumer A; Hong J; Neubauer C; Voorhees RM; Sabine P; Kelley AC; Ramakrishnan V. 2008. Insights into translational termination from the structure of RF2 bound to the ribosome. Science 322:953-956.

Selmer M; Duham CM; Murphy FV; Weixlbaumer A; Sabine P; Kelley AC; Weir JR; Ramakrishnan V. 2006. Science 313:1935-1942.

Petry S; Brodeson DE; Murphy FV; et al.  2005.  Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon.  Cell  123(7):1255-1266.

Ogle, JM; Murphy FV; Tarry MJ; et al.  2002. Selection of tRNA by the ribosome requires a transition from an open to a closed form.  Cell  111(5):721-732.

Wimberly BT; Brodeson DE; Clemons WM; et al.  Structure of the ribosomal subunit. 2000. NATURE   407(6802): 327-339.

Carter AP; Clemons WM; Broderson DE; et al.  2000.  Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics.  NATURE  407(6802):340-348.