Recommended Readings: Titia de Lange, Ph.D., December 7th

Monday Lecture Series
Monday, December 7, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Titia de Lange, Ph.D.
Leon Hess Professor and Head,
Laboratory of Cell Biology and Genetics,
The Rockefeller University

Telomere-derived Genome Instability in Cancer

Recommended Readings

Davoli, T., & de Lange, T. (2011). The causes and consequences of polyploidy in normal development and cancer. Annual review of cell and developmental biology, 27, 585-610. doi:10.1146/annurev-cellbio-092910-154234

Davoli, T., & de Lange, T. (2012). Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cellsCancer Cell, 21(6), 765-776. doi:10.1016/j.ccr.2012.03.044

de Lange, T. (2005). Telomere-related genome instability in cancer. Cold Spring Harbor Symposia on Quantitative Biology, 70, 197-204. doi:10.1101/sqb.2005.70.032

Recommended Readings: Titia de Lange, Ph.D.

Friday Lecture Series

Cancer Biology Lecture

How Telomeres Solved the End-protection Problem

Titia de Lange, Ph.D., Leon Hess Professor and head,

Laboratory of Cell Biology and Genetics,

The Rockefeller University

March 23, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

 

Recommended Readings:

Davoli, T., E. L. Denchi, and T. de Lange. 2010. “Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy.” Cell 141 (1): 81-93

Davoli, T. and T. De Lange. 2011. The Causes and Consequences of Polyploidy in Normal Development and Cancer. Annual Review of Cell and Developmental Biology. Vol. 27: 585-610

De Lange, T. 2009. “How Telomeres Solve the End-Protection Problem.” Science 326 (5955): 948-952

Gong, Y. and T. de Lange. 2010. “A Shld1-Controlled POT1a Provides Support for Repression of ATR Signaling at Telomeres through RPA Exclusion.” Molecular Cell 40 (3): 377-387

Kabir, S., A. Sfeir, and T. De Lange. 2010. “Taking Apart Rap1: An Adaptor Protein with Telomeric and Non-Telomeric Functions.” Cell Cycle 9 (20): 4061-4067

Palm, W. and T. De Lange. 2008. How Shelterin Protects Mammalian Telomeres. Annual Review of Genetics. Vol. 42.

Sfeir, A., S. Kabir, M. Van Overbeek, G. B. Celli, and T. De Lange. 2010. “Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ Or a DNA Damage Signal.” Science 327 (5973): 1657-1661

Sfeir, A., S. T. Kosiyatrakul, D. Hockemeyer, S. L. MacRae, J. Karlseder, C. L. Schildkraut, and T. de Lange. 2009. “Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication.” Cell 138 (1): 90-103

Scherthan, H., A. Sfeir, and T. De Lange. 2011. “Rap1-Independent Telomere Attachment and Bouquet Formation in Mammalian Meiosis.” Chromosoma 120 (2): 151-157