Recommended Readings: James P. Allison, Ph.D., Friday May 12th, 2017

Friday Lectures

Friday, May 2, 2017  3:45 p.m.

Caspary Auditorium

James P. Allison, Ph.D.

Professor and Vivian L. Smith Distinguished Chair of Immunology,

Executive Director of the Immunotherapy Platform

The University of Texas MD Anderson Cancer Center

Immune Checkpoint Blockade in Cancer Therapy: New Insights, Opportunities, and Prospects for a Cure

Recommended Readings:

http://thetartan.org/2017/5/1/scitech/immunotherapy

Hazarika M; Chuk MK; Theoret MR; et al. (2017). U.S. FDA Approval Summary: Nivolumab for Treatment of Unresectable or Metastatic Melanoma Following Progression on Ipilimumab.CLINICAL CANCER RESEARCH. doi: 10.1158/1078-0432

Medina, Patrick J.; Adams, Val R. (2016). PD-1 Pathway Inhibitors: Immuno-Oncology Agents for Restoring Antitumor Immune Responses. PHARMACOTHERAPY. 36(3): 317-334

Sharma, Padmanee; Allison, James P. (2015). Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential. CELL. 161(2): 205-214

Robert, Caroline; Schachter, Jacob; Long, Georgina V.; et al. (2015). Pembrolizumab versus Ipilimumab in Advanced Melanoma. NEW ENGLAND JOURNAL OF MEDICINE    372(26): 2521-2532

Sharma, Padmanee; Allison, James P. (2015). The future of immune checkpoint therapy. SCIENCE. 348(6230): 56-61

Gubin, Matthew M.; Zhang, Xiuli; Schuster, Heiko; et al. (2014). Checkpoint blockage cancer immunotherapy targets tumour-specific mutant antigens. NATURE. 515(7528): 577-+

Lipson, Evan J.; Drake, Charles G. (2011). Ipilimumab: An Anti-CTLA-4 Antibody for Metastatic Melanoma. CLINICAL CANCER RESEARCH. 17(22): 6958-6962

 

Recommended Readings: Hidde Ploegh, Ph.D.

Friday Lecture Series

Host-pathogen Interactions: A Biochemist’s Perspective

Hidde Ploegh, Ph.D., professor of biology and member,

Whitehead Institute for Biomedical Research

March 28, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Carette, J. E., Guimaraes, C. P., Varadarajan, M., Park, A. S., Wuethrich, I., Godarova, A., . . . Brummelkamp, T. R. (2009). Haploid genetic screens in human cells identify host factors used by pathogens. Science, 326(5957), 1231-1235

Dougan, S. K., Hu, C. -. A., Paquet, M. -., Greenblatt, M. B., Kim, J., Lilley, B. N., . . . Ploegh, H. L. (2011). Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Molecular and Cellular Biology, 31(6), 1145-1159

Loureiro, J., & Ploegh, H. L. (2006). Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions. Advances in Immunology, 92, 225-305

Reiling, J. H., Olive, A. J., Sanyal, S., Carette, J. E., Brummelkamp, T. R., Ploegh, H. L., . . . Sabatini, D. M. (2013). A CREB3-ARF4 signalling pathway mediates the response to golgi stress and susceptibility to pathogens. Nature Cell Biology, 15(12), 1473-1485

Tafesse, F. G., Sanyal, S., Ashour, J., Guimaraes, C. P., Hermansson, M., Somerharju, P., & Ploegh, H. L. (2013). Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins. Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6406-6411

Vyas, J. M., Van Der Veen, A. G., & Ploegh, H. L. (2008). The known unknowns of antigen processing and presentation. Nature Reviews Immunology, 8(8), 607-618

 

Recommended Readings: Diane Mathis, Ph.D.

Friday Lecture Series

The Ernst A.H. Friedheim Memorial Lecture

Aire, a Transcriptional Regulator Critical for Immunological Tolerance

Diane Mathis, Ph.D., professor, division of immunology,

department of microbiology and immunobiology, Harvard Medical School

March 21, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Abramson, J., Giraud, M., Benoist, C., & Mathis, D. (2010). Aire’s partners in the molecular control of immunological tolerance. Cell, 140(1), 123-135

Burzyn, D., Benoist, C., & Mathis, D. (2013). Regulatory T cells in nonlymphoid tissues. Nature Immunology, 14(10), 1007-1013

D’Alise, A. M., Ergun, A., Hill, J. A., Mathis, D., & Benoist, C. (2011). A cluster of coregulated genes determines TGF-β – induced regulatory T-cell (treg) dysfunction in NOD mice. Proceedings of the National Academy of Sciences of the United States of America, 108(21), 8737-8742

Fu, W., Ergun, A., Lu, T., Hill, J. A., Haxhinasto, S., Fassett, M. S., . . . Benoist, C. (2012). A multiply redundant genetic switch ‘locks in’ the transcriptional signature of regulatory T cells. Nature Immunology, 13(10), 972-980

Giraud, M., Yoshid, H., Abramson, J., Rahl, P. B., Young, R. A., Mathis, D., & Benoist, C. (2012). Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells. Proceedings of the National Academy of Sciences of the United States of America, 109(2), 535-540

Koh, A. S., Kingston, R. E., Benoist, C., & Mathis, D. (2010). Global relevance of aire binding to hypomethylated lysine-4 of histone-3. Proceedings of the National Academy of Sciences of the United States of America, 107(29), 13016-13021

Yang, S., Bansal, K., Lopes, J., Benoist, C., & Mathis, D. (2013). Aire’s plant homeodomain(PHD)-2 is critical for induction of immunological tolerance. Proceedings of the National Academy of Sciences of the United States of America, 110(5), 1833-1838

 

Recommended Readings: Michel C. Nussenzweig, M.D., Ph.D.

Friday Lecture Series

Ph.D. Recruitment Lecture

The HIV Vaccine Problem

Michel C. Nussenzweig, M.D., Ph.D., Sherman Fairchild Professor,

senior physician, The Rockefeller University;

investigator, Howard Hughes Medical Institute

 March 8, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

 

Recommended Readings

Mouquet, H., Warncke, M., Scheid, J. F., Seaman, M. S., & Nussenzweig, M. C. (2012). Enhanced HIV-1 neutralization by antibody heteroligation. Proceedings of the National Academy of Sciences of the United States of America, 109(3), 875-880

Nchinda, G., Kuroiwa, J., Oks, M., Trumpfheller, C., Chae, G. P., Huang, Y., . . . Steinman, R. M. (2008). The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells. Journal of Clinical Investigation, 118(4), 1427-1436

Scheid, J. F., Mouquet, H., Ueberheide, B., Diskin, R., Klein, F., Oliveira, T. Y. K., . . . Nussenzweig, M. C. (2011). Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science, 333(6049), 1633-1637

Trumpfheller, C., Finke, J. S., López, C. B., Moran, T. M., Moltedo, B., Soares, H., . . . Steinman, R. M. (2006). Intensified and protective CD4 + T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. Journal of Experimental Medicine, 203(3), 607-617

Zhou, T., Georgiev, I., Wu, X., Yang, Z. -., Dai, K., Finzi, A., . . . Kwong, P. D. (2010). Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01. Science, 329(5993), 811-817