Recommended Readings: Peter Reddien, Ph.D. Friday September 28, 2018

Friday Lectures

Friday, September 28, 2018  3:45 p.m.

Caspary Auditorium

Peter Reddien Ph.D.

Professor and Associate Department Head

Department of Biology

Massachusetts Institute of Technology

How Stem Cells and Positional Information Lead to Planarian Regeneration

Recommended Readings:

Science News

Lisa Girard. A blueprint for regeneration. March 15, 2018. MIT News

Empirical Articles

Fincher, Christopher T.; Wurtzel, Omri; de Hoog, Thom; et al. (2018). Cell type transcriptome atlas for the planarian Schmidtea mediterranea. SCIENCE.  360 (6391): 874-+

Atabay KD, LoCascio SA, de Hoog T, Reddien PW. (2018). Self-organization and progenitor targeting generate stable patterns in planarian regeneration. SCIENCE. 360 (6387):404-409

Scimone, M. Lucila; Cote, Lauren E.; Reddien, Peter W. (2017). Orthogonal muscle fibres have different instructive roles in planarian regeneration. NATURE. 551 (7682): 623-+  

Raz, Amelie A.; Srivastava, Mansi; Salvamoser, Ranja; et al. (2017). Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning. NATURE COMMUNCATIONS. 8

Wurtzel, Omri; Oderberg, Isaac M.; Reddien, Peter W. (2017). Planarian Epidermal Stem Cells Respond to Positional Cues to Promote Cell-Type Diversity. DEVELOPMENTAL CELL. 40 (5): 491-504  

Scimone, M. Lucila; Kravarik, Kellie M.; Lapan, Sylvain W.; et al. (2014). Neoblast Specialization in Regeneration of the Planarian Schmidtea mediterranea. STEM CELLS REPORTS. 3 (2): 339-352

van Wolfswinkel, Josien C.; Wagner, Daniel E.; Reddien, Peter W. (2014). Single-Cell Analysis Reveals Functionally Distinct Classes within the Planarian Stem Cell Compartment. CELL STEM CELL. 15 (3): 326-339

Wagner, Daniel E.; Wang, Irving E.; Reddien, Peter W. (2011). Clonogenic Neoblasts Are Pluripotent Adult Stem Cells That Underlie Planarian Regeneration. SCIENCE. 332 (6031): 811-816  

Review Paper

Tanaka, Elly M.; Reddien, Peter W. (2011). The Cellular Basis for Animal Regeneration. DEVELOPMENTAL CELL. 21 (1): 172-185

Reddien, Peter W. (2011). Constitutive gene expression and the specification of tissue identity in adult planarian biology.  TRENDS IN GENETICS. 27 (7): 277-285  

Book Chapter

Wang IE, Wagner DE, Reddien PW. (2018). Clonal Analysis of Planarian Stem Cells by Subtotal Irradiation and Single-Cell Transplantation. Planarian Regeneration. 1774:479-495

Recommended Readings: Elaine Fuchs, Ph.D. Friday February 23rd, 2018

Friday Lectures

Friday, February 23rd, 2018  3:45 p.m.

Caspary Auditorium

Elaine Fuchs, Ph.D.

Rebecca C. Lancefield Professor and Head

Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development

The Rockefeller University

Stem Cells in Silence, Action, and Cancer

Recommended Readings:

Science News

David Nield. Our Skin Can ‘Remember’ Inflammation, And It Could Help Us Understand Psoriasis. (2017, Oct 21). ScienceAlert

Empirical Articles

Naik, Shruti; Larsen, Samantha B.; Gomez, Nicholas C.; et al. (2017). Inflammatory memory sensitizes skin epithelial stem cells to tissue damage. NATURE. 550 (7677): 475-+

Ge, Yejing; Gomez, Nicholas C.; Adam, Rene C.; et al. (2017). Stem Cell Lineage Infidelity Drives Wound Repair and Cancer. CELL. 169 (4): 636-650

Yang, Hanseul; Adam, Rene C.; Ge, Yejing; et al. (2017). Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices. CELL. 69 (3): 483-+  

Asare, Amma; Levorse, John; Fuchs, Elaine. (2017). Coupling organelle inheritance with mitosis to balance growth and differentiation. SCIENCE. 355 (6324): 493-+

Sendoel, Ataman; Dunn, Joshua G.; Rodriguez, Edwin H.; et al. (2017). Translation from unconventional 5 ‘ start sites drives tumour initiation. NATURE. 541 (7638)

Lay, Kenneth; Kume, Tsutomu; Fuchs, Elaine (2016). FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential. PNAS. 113 (11): E1506-E1515

Ouspenskaia, Tamara; Matos, Irina; Mertz, Aaron F.; et al. (2016). WNT-SHH Antagonism Specifies and Expands Stem Cells prior to Niche Formation. CELL. 164 (1-2): 156-169

Yang, Hanseul; Schramek, Daniel; Adam, Rene C.; et al. (2015). ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas. ELIFE. 4. # e10870

Review Papers

Gonzales, Kevin Andrew Uy; Fuchs, Elaine (2017). Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche.  DEVELOPMENTAL CELL. 43 (4): 387-401

Blanpain, Cedric; Fuchs, Elaine (2014). STEM CELL PLASTICITY Plasticity of epithelial stem cells in tissue regeneration. SCIENCE. 344 (6189): 1243-+

Hsu, Ya-Chieh; Li, Lishi; Fuchs, Elaine (2014). Emerging interactions between skin stem cells and their niches. NATURE MEDICINE. 20 (8): 847-856

Book Chapter

Fuchs, Elaine (2016). Epithelial Skin Biology: Three Decades of Developmental Biology, a Hundred Questions Answered and a Thousand New Ones to Address. ESSAYS ON DEVELOPMENTAL BIOLOGY, PT A  Book Series: Current Topics in Developmental Biology. 116: 357-+  

 

Recommended Readings: Elly Tanaka, Ph.D. March 17, 2017

Friday Lectures

Friday, March 17, 2017   3:45 p.m.

Caspary Auditorium

Elly Tanaka, Ph.D.

Senior Scientist,

Research Institute of Molecular Pathology, Vienna, Austria

The Control of Growth, Signaling, and Patterning during Vertebrate Limb Regeneration

Recommended Readings:

https://medicalxpress.com/news/2017-03-inflammation-regeneration-friend-foe.html

Tanaka, Elly M. (2016). The Molecular and Cellular Choreography of Appendage on Regeneration. CELL. 165(7): 1598-1608

Tornini, Valerie A.; Puliafito, Alberto; Slota, Leslie A.; et al. (2016). Live Monitoring of Blastemal Cell Contributions during Appendage Regeneration. CURRENT BIOLOGY. 26(22): 2981-2991 

Sandoval-Guzman, Tatiana; Wang, Heng; Khattak, Shahryar; et al. (2014). Fundamental Differences in Dedifferentiation and Stem Cell Recruitment during Skeletal Muscle Regeneration in Two Salamander Species. CELL STEM CELL. 14(2): 174-187

Khattak, Shahryar; Schuez, Maritta; Richter, Tobias; et al. (2013). Germline Transgenic Methods for Tracking Cells and Testing Gene Function during Regeneration in the Axolotl. STEM CELL REPORTS. 1(1): 90-103

Simon, Andras; Tanaka, Elly M. (2013). Limb regeneration.  WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY. 2(2): 291-300

Recommended Readings: Elaine Fuchs PhD October 24, 2016

Monday Lecture Series

Monday October 24, 2016   3:45 p.m.

Caspary Auditorium

Elaine Fuchs, Ph.D.

Rebecca Lancefield Professor

Laboratory of Mammalian Cell Biology and Development

Skin Stem Cells in Silence, Action and Cancer

Recommended Readings:

Quist, S. R.; Eckardt, M.; Kriesche, A.; et al.  Expression of epidermal stem cell markers in skin and adnexal malignancies. BRITISH JOURNAL OF DERMATOLOGY   175(3):520-530     SEP 2016

 Holland, Jane D.; Klaus, Alexandra; Garratt, Alistair N.; et al.  Wnt signaling in stem and cancer stem cells.  CURRENT OPINION IN CELL BIOLOGY    25(2):254-264  APR 2013

Arwert, Esther N.; Hoste, Esther; Watt, Fiona M.    Epithelial stem cells, wound healing and cancer.  NATURE REVIEWS CANCER   12(3):170-180   MAR 2012

Blanpain, Cedric; Fuchs, Elaine  STEM CELL PLASTICITY Plasticity of epithelial stem cells in tissue regeneration.  SCIENCE   344(6189):1243-+  ( Article Number: 1242281)  JUN 13 2014

Hsu, Ya-Chieh; Li, Lishi; Fuchs, Elaine  Transit-Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration. CELL   157(4):935-949     MAY 8 2014

Fuchs, Elaine; Chen, Ting  A matter of life and death: self-renewal in stem cells.  EMBO REPORTS   14 (1): 39-48   JAN 2013 

Oshimori, Naoki; Fuchs, Elaine   The Harmonies Played by TGF-beta in Stem Cell Biology.    CELL STEM CELL   11(6):751-764    DEC 7 2012

Recommended Readings: James Wells, Ph.D., February 5

Friday Lecture Series
Friday, February 5, 2016
3:45 p.m., Carson Family Caspary Auditorium

James M. Wells, Ph.D.
Professor of Pediatrics,
Perinatal Institute Endowed Professor,
Division of Development Biology,
Director for Basic Research,
Division of Endocrinology,
Cincinnati Children’s Hospital Medical Center

Pluripotent Stem Cell-based Models of Human Gastrointestinal Development and Disease

Recommended Reading

Empirical Articles

McCracken, K. W., Catá, E. M., Crawford, C. M., Sinagoga, K. L., Schumacher, M., Rockich, B. E., … & Wells, J. M. (2014). Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature. 516(7531):400-404. doi: 10.1038/nature13863.

Spence, J. R., Mayhew, C. N., Rankin, S. A., Kuhar, M. F., Vallance, J. E., Tolle, K., … & Shroyer, N. F. (2011). Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature, 470(7332), 105-109. doi: 10.1038/nature09691

Watson, C. L., Mahe, M. M., Múnera, J., Howell, J. C., Sundaram, N., Poling, H. M., … & Grabowski, G. (2014). An in vivo model of human small intestine using pluripotent stem cells. Nature Medicine, 20(11), 1310-1314. doi: 10.1038/nm.3737

Review Papers

Sinagoga, K. L., & Wells, J. M. (2015). Generating human intestinal tissues from pluripotent stem cells to study development and disease. The EMBO Journal, 34(9):1149-63. doi: 10.15252/embj.201490686

Wells, J. M., & Spence, J. R. (2014). How to make an intestine. Development, 141(4), 752-760. doi: 10.1242/dev.097386.

Recommended Readings: Joanna Wysocka, Ph.D., November 13th

Friday Lecture Series
Friday, November 13, 2015
3:45 p.m., Caspary Auditorium

Joanna Wysocka, Ph.D.
Professor,
Department of Chemical and Systems Biology,
Department of Developmental Biology,
Stanford University

On Peculiarities of Being a Human: Gene Regulatory Mechanisms in Human Development and Evolution

Recommended Readings

Empirical Articles

Buecker, C., Srinivasan, R., Wu, Z., Calo, E., Acampora, D., Faial, T., … & Wysocka, J. (2014). Reorganization of enhancer patterns in transition from naive to primed pluripoteny. Cell Stem Cell, 14(6), 838-853. doi:10.1016/j.stem.2014.04.003

Grow, E. J., Flynn, R. A., Chavez, S. L., Bayless, N. L., Wossidlo, M., Wesche, D. J., … & Wysocka, J. (2015). Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells. Nature. 522(7555), 221-225. doi:10.1038/nature14308

Prescott, S. L., Srinivasan, R., Marchetto, M. C., Grishina, I., Narvaiza, I., Selleri, L., … & Wysocka, J. (2015). Enhancer divergence and cis-regulatory evolution in the human and chimp neural crest. Cell, 163(1), 68-83. doi:10.1016/j.cell.2015.08.036

Review Papers

Calo, E., & Wysocka, J. (2013). Modification of enhancer chromatin: what, how, and why?. Molecular Cell, 49(5), 825-837. doi:10.1016/j.molcel.2013.01.038

Buecker, C., & Wysocka, J. (2012). Enhancers as information integration hubs in development: lessons from genomics. Trends in Genetics, 28(6), 276-284. doi:10.1016/j.tig.2012.02.008

Recommended Readings: Rudolf Jaenisch, M.D. December 12

Friday Lecture Series
Friday, December 12, 2014
3:45 p.m., Caspary Auditorium

Rudolf Jaenisch, M.D.
Professor of Biology,
Massachusetts Institute of Technology
Member,
Whitehead Institute for Biomedical Research

iPS Cell Technology, Gene Editing and Disease Research

Recommended Readings

Empirical Articles

Chung, C. Y., Khurana, V., Auluck, P. K., Tardiff, D. F., Mazzulli, J. R., Soldner, F., … Lindquist, S. (2013). Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science, 342(6161), 983–987. doi:10.1126/science.1245296

Li, Y., Wang, H., Muffat, J., Cheng, A. W., Orlando, D. a, Lovén, J., … Jaenisch, R. (2013). Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell, 13(4), 446–458. doi:10.1016/j.stem.2013.09.001

Soldner, F., Laganière, J., Cheng, A. W., Hockemeyer, D., Gao, Q., Alagappan, R., … Jaenisch, R. (2011). Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell, 146(2), 318–331. doi:10.1016/j.cell.2011.06.019

Wang, H., Yang, H., Shivalila, C. S., Dawlaty, M. M., Cheng, A. W., Zhang, F., & Jaenisch, R. (2013). One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell, 153(4), 910–918. doi:10.1016/j.cell.2013.04.025

Review Papers

Buganim, Y., Faddah, D. A., & Jaenisch, R. (2013). Mechanisms and models of somatic cell reprogramming. Nature Reviews Genetics, 14(6), 427–439. doi:10.1038/nrg3473

Theunissen, T. W., & Jaenisch, R. (2014). Molecular Control of Induced Pluripotency. Cell Stem Cell, 14(6), 720–734. doi:10.1016/j.stem.2014.05.002

Recommended Readings: Elaine Fuchs, Ph.D. November 3

Monday Lecture Series
Monday, November 3, 2014
4:00 p.m., Carson Family Auditorium

Elaine Fuchs, Ph.D.
Rebecca C. Lancefield Professor and Head,
Laboratory of Mammalian Cell Biology and Development,
The Rockefeller University
Investigator,
Howard Hughes Medical Institute

Stem Cells in Silence, Action and Cancer

Recommended Readings

Empirical Articles

Blanpain, C., Lowry, W., & Geoghegan, A. (2004). Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell, 118(5), 635–648. doi:10.1016/j.cell.2004.08.012

Lechler, T., & Fuchs, E. (2005). Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature, 437(7056), 275–280. doi:10.1038/nature03922

Yi, R., Poy, M. N., Stoffel, M., & Fuchs, E. (2008). A skin microRNA promotes differentiation by repressing “stemness”. Nature, 452(7184), 225–9. doi:10.1038/nature06642

Review Papers

Fuchs, E., Tumbar, T., & Guasch, G. (2004). Socializing with the neighbors: stem cells and their niche. Cell, 116(6), 769–778. doi:10.1016/S0092-8674(04)00255-7

Hsu, Y.-C., Li, L., & Fuchs, E. (2014). Emerging interactions between skin stem cells and their niches. Nature Medicine, 20(8), 847–856. doi:10.1038/nm.3643

Recommended Readings: Allan C Spradling, Ph.D. May 16

Friday Lecture Series
Friday, May 16, 2014
3:45 p.m., Caspary Auditorium

Allan C Spradling, Ph.D.
Director, Department of Embryology
Carnegie Institution for Science

Investigator, Howard Hughes Medical Institute

Epigenetic and genetic programing of Drosophila development

Recommended Readings:

Empirical Articles

Morris, L. X., & Spradling, A. C. (2011). Long-term live imaging provides new insight into stem cell regulation and germline-soma coordination in the Drosophila ovary. Development, 138(11), 2207–2215. doi:10.1242/dev.065508

Nystul, T., & Spradling, A. (2007). An epithelial niche in the Drosophila ovary undergoes long-range stem cell replacement. Cell Stem Cell, 1(3), 277–285. doi:10.1016/j.stem.2007.07.009

Skora, A. D., & Spradling, A. C. (2010). Epigenetic stability increases extensively during Drosophila follicle stem cell differentiation. Proceedings of the National Academy of Sciences, 107(16), 7389–7394. doi:10.1073/pnas.1003180107

Xie, T., & Spradling, A. C. (2000). A niche maintaining germ line stem cells in the Drosophila ovary. Science, 290(5490), 328–330. doi:10.1126/science.290.5490.328

Review Papers

Losick, V. P., Morris, L. X., Fox, D. T., & Spradling, A. (2011). Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation. Developmental Cell, 21(1), 159–171. doi:10.1016/j.devcel.2011.06.018

Morrison, S. J., & Spradling, A. C. (2008). Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell, 132(4), 598–611. doi:10.1016/j.cell.2008.01.038

Recommended Readings: Madeline Lancaster, Ph.D. Monday, Dec. 11

Special Lecture
The Human Brain in a Dish: Using Cerebral Organoids to Model Development and Disease
Madeline A. Lancaster, Ph.D.
Postdoctoral Fellow
Institute of Molecular Biotechnology
4:00 p.m., Carson Family Auditorium

Recommended Readings

Review Papers

Eiraku, M., & Sasai, Y. (2012). Self-formation of layered neural structures in three-dimensional culture of ES cells. Current Opinion in Neurobiology, 22(5), 768–777. doi:10.1016/j.conb.2012.02.005

Gage, F. H., & Temple, S. (2013). Neural stem cells: generating and regenerating the brain. Neuron, 80(3), 588–601. doi:10.1016/j.neuron.2013.10.037

Han, S. S. W., Williams, L. a, & Eggan, K. C. (2011). Constructing and deconstructing stem cell models of neurological disease. Neuron, 70(4), 626–644. doi:10.1016/j.neuron.2011.05.003

Lui, J. H., Hansen, D. V, & Kriegstein, A. R. (2011). Development and evolution of the human neocortex. Cell, 146(1), 18–36. doi:10.1016/j.cell.2011.06.030

Empirical Articles

Espuny-Camacho, I., Michelsen, K. a, Gall, D., Linaro, D., Hasche, A., Bonnefont, J., … Vanderhaeghen, P. (2013). Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo. Neuron, 77(3), 440–456. doi:10.1016/j.neuron.2012.12.011

Lancaster, M. a, Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., … Knoblich, J. a. (2013). Cerebral organoids model human brain development and microcephaly. Nature, 501(7467), 373–379. doi:10.1038/nature12517

Mariani, J., Simonini, M. V., Palejev, D., Tomasini, L., Coppola, G., Szekely, A. M., … Vaccarino, F. M. (2012). Modeling human cortical development in vitro using induced pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America, 109(31), 12770–12775. doi:10.1073/pnas.1202944109