Recommended Readings; Gregory J. Hannon, Ph.D., Friday, May 29th

Friday Lecture Series

Richard M. Furlaud Distinguished Lecture

“Conserved Roles of Small RNAs in Genome Defense”

Gregory J. Hannon, Ph.D., professor and chair, program in genetics and bioinformatics, Cold Spring Harbor Laboratory; investigator, Howard Hughes Medical Institute

May 29, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Malone, C. D., J. Brennecke, M. Dus, A. Stark, W. R. McCombie, R. Sachidanandam, and G. J. Hannon. 2009. Specialized piRNA pathways act in germline and somatic tissues of the drosophila ovary. Cell. 137:522–535.

 

Czech, B., C. D. Malone, R. Zhou, A. Stark, C. Schlingeheyde, M. Dus, N. Perrimon, et al. 2008. An endogenous small interfering RNA pathway in Drosophila. Nature. 453(7196):798-802.

 

Tam, O. H., A. A. Aravin, P. Stein, A. Girard, E. P. Murchison, S. Cheloufi, E. Hodges, et al. 2008. Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature. 453(7194):534-538.

 

Zhou, R., I. Hotta, A. M. Denli, P. Hong, N. Perrimon, and G. J. Hannon. 2008. Comparative analysis of argonaute-dependent small RNA pathways in Drosophila. Molecular Cell. 32(4):592-599.

 

Aravin, A. A., G. J. Hannon, and J. Brennecke. 2007. The piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science. 318(5851): 761-764.

 

Brennecke, J., C. D. Malone, A. A. Aravin, R. Sachidanandam, A. Stark, and G. J. Hannon. 2008. An epigenetic role for maternally inherited piRNAs in transposon silencing. Science. 322(5906): 1387-1392.

 

Girard, A., and G. J. Hannon. 2008. Conserved themes in small-RNA-mediated transposon control. Trends in Cell Biology. 18(3)136-148.

 

Reviews

 

Kim, V. N., J. Han, and M. C. Siomi. 2009. Biogenesis of small RNAs in animals. Nature Reviews Molecular Cell Biology. 10(2):126-139.

Siomi, H., and M. C. Siomi. 2009. On the road to reading the RNA-interference code. Nature. 457(7228):396-404.

Malone, C. D., and G. J. Hannon. 2009. Small RNAs as guardians of the genome. Cell. 136(4):656-668.

Recommended Readings: Jennifer A. Doudna, Ph.D.; May 8, 2009

Friday Lecture Series

“Dicer and Beyond: Regulatory RNA Processing and Function”

Jennifer A. Doudna, Ph.D., professor, departments of molecular and cell biology and of chemistry; investigator, Howard Hughes Medical Institute

University of California, Berkeley

May 8, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Aggarwal, A. K., and J. A. Doudna. 2005. Protein-nucleic acid interactions: Unlocking mysteries old and new. Current opinion in structural biology. 15(1 SPEC. ISS.):65-67.

 

Fukunaga, R., and J. A. Doudna. 2009. dsRNA with 5′ overhangs contributes to endogenous and antiviral RNA silencing pathways in plants. EMBO Journal. 28(5):545-555.

 

Jinek, M., and J. A. Doudna. 2009. A three-dimensional view of the molecular machinery of RNA interference. Nature. 457(7228):405-412.

 

Ma, E., I. J. MacRae, J. F. Kirsch, and J. A. Doudna. 2008. Autoinhibition of human dicer by its internal helicase domain. Journal of Molecular Biology. 380(1):237-243.

 

MacRae, I. J., and J. A. Doudna. 2007. Ribonuclease revisited: Structural insights into ribonuclease III family enzymes. Current opinion in structural biology. 17(1):138-145.

 

MacRae, I. J., K. Zhou, and J. A. Doudna. 2007. Structural determinants of RNA recognition and cleavage by dicer. Nature Structural and Molecular Biology. 14(10):934-940.

 

MacRae, I. J., K. Zhou, F. Li, A. Repic, A. N. Brooks, W. Z. Cande, P. D. Adams, and J. A. Doudna. 2006. Structural basis for double-stranded RNA processing by dicer. Science. 311(5758):195-198.

A New Class of Small RNA Molecules Found at CSHL

The vast bulk of the DNA in our genomes does not “code” for the specific RNA molecules that serve as templates for protein synthesis, but nevertheless performs various other kinds of work.   At Cold Spring Harbor Laboratory David L. Spector, Ph.D., has lead studies of events within the cell nucleus, where the genetic material is contained. In the November 26th issue of Cell, Spector and a team led by graduate student Jeremy Wilusz report their discovery of a previously unknown mechanism in the nucleus that processes non-coding RNA molecules.   Read the details in Cell.