Recommended Readings: Beth Stevens, Ph.D. Friday May 4, 2018

Friday Lectures

Friday, May 4, 2018  3:45 p.m.

Caspary Auditorium

Beth Stevens Ph.D.

Associate Professor

Department of Neurology

Harvard Medical School – Boston Children’s Hospital

How the Immune System Sculpts Brain Circuitry

Recommended Readings:

Science News

Beth Stevens and Todd E. Golden. Deciphering neurodegeneration: Inflammation, immune response, and Alzheimer’s. (Webinar – February 7, 2018). Science

Empirical Articles

Shi, Qiaoqiao; Chowdhury, Saba; Ma, Rong; et al. (2017). Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. SCIENCE TRANSLATIONAL MEDICINE. 9 (392)

Hong, Soyon; Beja-Glasser, Victoria F.; Nfonoyim, Bianca M.; et al. (2016). Complement and microglia mediate early synapse loss in Alzheimer mouse models. SCIENCE. 352 (6286): 712-716

Vasek, Michael J.; Garber, Charise; Dorsey, Denise; et al. (2016). A complement-microglial axis drives synapse loss during virus-induced memory impairment. NATURE. 534 (7608): 538-+

Sekar, Aswin; Bialas, Allison R.; de Rivera, Heather; et al. (2016). Schizophrenia risk from complex variation of complement component 4. NATURE. 530 (7589): 177-+

Schafer, Dorothy P.; Lehrman, Emily K.; Heller, Christopher T.; et al. (2014). An Engulfment Assay: A Protocol to Assess Interactions Between CNS Phagocytes and Neurons. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 88

Schafer, Dorothy P.; Lehrman, Emily K.; Kautzman, Amanda G.; et al. (2012). Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner. NEURON. 74 (4): 691-705

Review Paper

Salter, Michael W.; Stevens, Beth. (2017). Microglia emerge as central players in brain disease. NATURE MEDICINE. 23 (9): 1018-1027

Hong, Soyon; Dissing-Olesen, Lasse; Stevens, Beth. (2016). New insights on the role of microglia in synaptic pruning in health and disease. CURRENT OPINION IN NEUROBIOLOGY. 36: 128-134  

Bilimoria, Parizad M.; Stevens, Beth. (2015). Microglia function during brain development: New insights from animal models. BRAIN RESEARCH. 1617: 7-17  

Book Chapter

Stephan, Alexander H.; Barres, Ben A.; Stevens, Beth. (2012). The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease.  ANNUAL REVIEW OF NEUROSCIENCE. 35: 369-389

Recommended Readings: Thomas Südhof, M.D. December 5

Friday Lecture Series
Friday, December 5, 2014
3:45 p.m., Caspary Auditorium

Thomas Südhof, M.D.
Avram Goldstein Professor,
Department of Molecular and Cellular Physiology,
Stanford School of Medicine
Howard Hughes Medical Institute

Cracking the Neurexin Code – Towards a Molecular Logic of Neural Circuits

Recommended Readings

Empirical Articles

Gokce, O., & Südhof, T. C. (2013). Membrane-tethered monomeric neurexin LNS-domain triggers synapse formation. The Journal of Neuroscience, 33(36), 14617–14628. doi:10.1523/JNEUROSCI.1232-13.2013

Rothwell, P. E., Fuccillo, M. V, Maxeiner, S., Hayton, S. J., Gokce, O., Lim, B. K., … Südhof, T. C. (2014). Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors. Cell, 158(1), 198–212. doi:10.1016/j.cell.2014.04.045

Treutlein, B., Gokce, O., Quake, S. R., & Südhof, T. C. (2014). Cartography of neurexin alternative splicing mapped by single-molecule long-read mRNA sequencing. Proceedings of the National Academy of Sciences, 111(13), E1291–E1299. doi:10.1073/pnas.1403244111

Tsetsenis, T., Boucard, a. a., Arac, D., Brunger, a. T., & Sudhof, T. C. (2014). Direct visualization of trans-synaptic neurexin-neuroligin interactions during synapse formation. Journal of Neuroscience, 34(45), 15083–15096. doi:10.1523/JNEUROSCI.0348-14.2014

Review Articles

Südhof, T. C. (2008). Neuroligins and neurexins link synaptic function to cognitive disease. Nature, 455(7215), 903–911. doi:10.1038/nature07456

Südhof, T. C. (2014). The molecular machinery of neurotransmitter release (Nobel Lecture). Angewandte Chemie, 53(47), 12696–12717. doi:10.1002/anie.201406359