Recommended Readings: Jorge E. Galán, Ph.D., DVM, February 6

Friday Lecture Series
Friday, February 6, 2015
3:45 p.m., Caspary Auditorium

Jorge E. Galán, Ph.D., DVM
Lucille P. Markey Professor of Microbial Pathogenesis,
Professor of Cell Biology,
Chair, Department of Microbial Pathogenesis,
Yale University School of Medicine

Typhoid fever: new insight into the pathogenesis of an old disease

Recommended Readings

Empirical Articles

Lefebre, M. D., & Galán, J. E. (2014). The inner rod protein controls substrate switching and needle length in a Salmonella type III secretion system. Proceedings of the National Academy of Sciences, 111(2), 817–822. doi:10.1073/pnas.1319698111

Song, J., Gao, X., & Galán, J. E. (2013). Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin. Nature, 499(7458), 350–354. doi:10.1038/nature12377

Spanò, S., & Galán, J. E. (2012). A Rab32-dependent pathway contributes to Salmonella typhi host restriction. Science, 338(6109), 960–963. doi:10.1126/science.1229224

Review Papers

Hicks, S. W., & Galán, J. E. (2013). Exploitation of eukaryotic subcellular targeting mechanisms by bacterial effectors. Nature Reviews Microbiology, 11(5), 316–326. doi:10.1038/nrmicro3009

Recommended Readings: Howard Hang, Ph.D. November 17

Monday Lecture Series
Monday, November 17, 2014,
4:00 p.m., Carson Family Auditorium (CRC)

Howard Hang, Ph.D.
Professor and Head,
Laboratory of Chemical Biology and Microbial Pathogenesis,
The Rockefeller University

A C. elegans Model for Commensal Bacteria Function Reveals a Secreted Peptidoglycan Hydrolase Activator of Host Immunity

Recommended Readings

Empirical Articles

Charron, G., Zhang, M. M., Yount, J. S., Wilson, J., Raghavan, A. S., Shamir, E., & Hang, H. C. (2009). Robust fluorescent detection of protein fatty-acylation with chemical reporters. Journal of the American Chemical Society, 131(13), 4967–4975. doi:10.1021/ja810122f

Hang, H. C., Geutjes, E.-J., Grotenbreg, G., Pollington, A. M., Bijlmakers, M. J., & Ploegh, H. L. (2007). Chemical probes for the rapid detection of Fatty-acylated proteins in Mammalian cells. Journal of the American Chemical Society, 129(10), 2744–2745. doi:10.1021/ja0685001

Yount, J. S., Moltedo, B., Yang, Y.-Y., Charron, G., Moran, T. M., López, C. B., & Hang, H. C. (2010). Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3. Nature Chemical Biology, 6(8), 610–614. doi:10.1038/nchembio.405

Review Paper

Grammel, M., & Hang, H. C. (2013). Chemical reporters for biological discovery. Nature Chemical Biology, 9(8), 475–484. doi:10.1038/nchembio.1296

Salmonella Targets Specific Cells to Facilitate Crossing The Gut Wall

Scientists have gained fresh insights into how the salmonella bug makes us ill. University of Edinburgh researchers have found that the bacteria are able to change key cells that line the intestine, enabling the bugs to thrive. 

By changing the make-up of these cells, the salmonella bacteria are able to cross the gut wall.   Research was reported in Cell Host and Microbe. 

Broad Spectrum Vaccine Under Development at UCSB

Scientists at UC Santa Barbara in collaboration with research partners at the University of Utah are developing a broad spectrum vaccine that will protect against hundreds of strains of Salmonella.  The research, published in the November 2008 issue of Infection and Immunity, works by disarming a genetic switch.  As an additional benefit the vaccine does NOT induce inhibitory immune cells known to cause immune declines in cancer patients.   The vaccine is still in re-clinical testing.