Recommended Readings: Angelika Amon, Ph.D., May 27

Friday Lecture Series
Friday, May 27, 2016
3:45 p.m., Caspary Auditorium

Angelika Amon, Ph.D.
Kathleen and Curtis Marble Professor of Cancer Research,
Koch Institute for Integrative Cancer Research,
Massachusetts Institute of Technology
Investigator, Howard Hughes Medical Institute

The Causes and Consequences of Aneuploidy

Recommended Readings:

Sheltzer, J. M., Blank, H. M., Pfau, S. J., Tange, Y., George, B. M., Humpton, T. J., … & Amon, A. (2011). Aneuploidy drives genomic instability in yeast. Science, 333(6045), 1026-1030. doi: 10.1126/science.1206412.

Sheltzer, J. M., Torres, E. M., Dunham, M. J., & Amon, A. (2012). Transcriptional consequences of aneuploidy. Proceedings of the National Academy of Sciences, 109(31), 12644-12649. doi: 10.1073/pnas.1209227109.

Tang, Y. C., & Amon, A. (2013). Gene copy-number alterations: a cost-benefit analysis. Cell, 152(3), 394-405. doi: 10.1016/j.cell.2012.11.043.

Torres, E. M., Sokolsky, T., Tucker, C. M., Chan, L. Y., Boselli, M., Dunham, M. J., & Amon, A. (2007). Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science, 317(5840), 916-924. doi: 10.1126/science.1142210

Recommended Readings: Jef Boeke, Ph.D., March 13

Friday Lecture Series
Friday, March 13, 2015
3:45 p.m., Caspary Auditorium

Jef Boeke, Ph.D.
Department of Biochemistry and Molecular Pharmacology,
Director, Institute for systems genetics,
New York University

Synthesis of Designer Chromosomes from Scratch

Recommended Readings

Empirical Articles

Annaluru, N., Muller, H., Mitchell, L. a, Ramalingam, S., Stracquadanio, G., Richardson, S. M., … Chandrasegaran, S. (2014). Total synthesis of a functional designer eukaryotic chromosome. Science, 344(6179), 55–58. doi:10.1126/science.1249252

Dymond, J. S., Richardson, S. M., Coombes, C. E., Babatz, T., Muller, H., Annaluru, N., … Boeke, J. D. (2011). Synthetic chromosome arms function in yeast and generate phenotypic diversity by design. Nature, 477(7365), 471–476. doi:10.1038/nature10403

Mitchell, L. a., & Boeke, J. D. (2014). Circular permutation of a synthetic eukaryotic chromosome with the telomerator. Proceedings of the National Academy of Sciences, 111(48), 17003–17010. doi:10.1073/pnas.1414399111

Reviews and Protocols

Cooper, E. M., Müller, H., Chandrasegaran, S., Bader, J. S., & Boeke, J. D. (2012). The build-a-genome course. Methods in Molecular Biology, 852, 273–283. doi:10.1007/978-1-61779-564-0_20

Recommended Readings: Susan Lindquist, Ph.D. October 17

Friday Lecture Series
Friday, October 17, 2014
3:45 p.m., Caspary Auditorium

Susan Lindquist, Ph.D.
Professor of Biology,
Massachussetts Institute of Technology
Whitehead Institute for Biomedical Research
Howard Hughes Medical Institute

From Yeast to Patient Neurons and Back Again: Powerful Discovery Platforms Combatting Neurodegenerative Disease

Recommended Readings

Empirical Articles

Chung, C. Y., Khurana, V., Auluck, P. K., Tardiff, D. F., Mazzulli, J. R., Soldner, F., … Lindquist, S. (2013). Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science, 342(6161), 983–987. doi:10.1126/science.1245296

Tardiff, D. F., Jui, N. T., Khurana, V., Tambe, M. A, Thompson, M. L., Chung, C. Y., … Lindquist, S. (2013). Yeast reveal a “druggable” Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science, 342(6161), 979–983. doi:10.1126/science.1245321

Treusch, S., Hamamichi, S., Goodman, J. L., Matlack, K. E. S., Chung, C. Y., Baru, V., … Lindquist, S. (2011). Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer’s disease risk factors in yeast. Science, 334(6060), 1241–1245. doi:10.1126/science.1213210

Review Papers

Khurana, V., & Lindquist, S. (2010). Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker’s yeast? Nature Reviews Neuroscience, 11(6), 436–449. doi:10.1038/nrn2809

Tardiff, D. F., Khurana, V., Chung, C. Y., & Lindquist, S. (2014). From yeast to patient neurons and back again: A powerful new discovery platform. Movement Disorders, 29(10), 1231–1240. doi:10.1002/mds.25989

Recommended Readings: Frederick Cross Ph.D. September 23, 2013

Monday Lecture Series
A Fast Route to Cell Cycle Control in the Plant Superkingdom
Frederick Cross, Ph.D.
Professor, Laboratory of Cell Cycle Genetics
The Rockefeller University
4:00 p.m. – 5:00 p.m. Carson Family Auditorium (CRC)
Refreshments: 3:45 p.m. – 4:00 p.m., Lower Level Greenberg Building (CRC) 

Recommended Readings:

Review Papers

Bloom, J., & Cross, F. R. (2007). Multiple levels of cyclin specificity in cell-cycle control. Nature Reviews Molecular and Cell Biology, 8(2), 1491–1560. doi:10.1038/nrm2105

Cross, F. R., Buchler, N. E., & Skotheim, J. M. (2011). Evolution of networks and sequences in eukaryotic cell cycle control. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 366(1584), 3532–3544. doi:10.1098/rstb.2011.0078

Harris, E. (2001). Chlamydomonas as a model organism. Annual Review of Plant Biology, 52, 363–406. doi:10.1146/annurev.arplant.52.1.363

Empirical Papers

Bisova, K., Krylov, D. M., & Umen, J. G. (2005). Genome-wide annotation and expression profiling of cell cycle regulatory genes in Chlamydomonas reinhardtii. Plant Physiology, 137, 475–491. doi:10.1104/pp.104.054155.G1-S-G2-M

Fang, S.-C., de los Reyes, C., & Umen, J. G. (2006). Cell size checkpoint control by the retinoblastoma tumor suppressor pathway. PLoS Genetics, 2(10), e167. doi:10.1371/journal.pgen.0020167

Koff, a, Cross, F., Fisher, a, Schumacher, J., Leguellec, K., Philippe, M., & Roberts, J. M. (1991). Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell, 66(6), 1217–1228.

Olson, B. J. S. C., Oberholzer, M., Li, Y., Zones, J. M., Kohli, H. S., Bisova, K., … Umen, J. G. (2010). Regulation of the Chlamydomonas cell cycle by a stable, chromatin-associated retinoblastoma tumor suppressor complex. The Plant Cell, 22(10), 3331–3347. doi:10.1105/tpc.110.076067

Richardson, H. E., Wittenberg, C., Cross, F., & Reed, S. I. (1989). An essential G1 function for cyclin-like proteins in yeast. Cell, 59(6), 1127–1133.