Recommended Readings: Sebastian Klinge, Ph.D. Friday April 12, 2019

Friday Lectures

Friday, April 12, 2019  3:45 p.m

Caspary Auditorium

Sebastian Klinge Ph.D.

Assistant Professor and Head

Laboratory of Protein and Nucleic Acid Chemistry

The Rockefeller University

Nucleolar Assembly of the Small Ribosomal Subunit


Recommended Readings:

Empirical Articles

Chaker-Margot, Malik; Klinge, Sebastian. (2019). Assembly and early maturation of large subunit precursors. RNA. 25 (4): 465-471

Chaker-Margot, Malik; Barandun, Jonas; Hunziker, Mirjam; et al. (2017). Architecture of the yeast small subunit processome. SCIENCE. 355 (6321)

Barandun, Jonas; Chaker-Margot, Malik; Hunziker, Mirjam; et al. (2017). The complete structure of the small-subunit processome. NATURE STRUCTURAL AND MOLECULAR BIOLOGY. 24 (11): 944-+

Hunziker, Mirjam; Barandun, Jonas; Petfalski, Elisabeth; et al. (2016). UtpA and UtpB chaperone nascent pre-ribosomal RNA and U3 snoRNA to initiate eukaryotic ribosome assembly. NATURE COMMUNICATIONS. 7

Chaker-Margot, Malik; Hunziker, Mirjam; Barandun, Jonas; et al. (2015). Stage-specific assembly events of the 6-MDa small-subunit processome initiate eukaryotic ribosome biogenesis. NATURE STRUCTURAL AND MOLECULAR BIOLOGY. 22 (11): 920-923

Review Papers

Klinge, Sebastian; Woolford, John L., Jr. (2019). Ribosome assembly coming into focus. NATURE REVIEWS MOLECULAR CELL BIOLOGY. 20 (2): 116-131

Barandun, Jonas; Hunziker, Mirjam; Klinge, Sebastian. (2018). Assembly and structure of the SSU processome-a nucleolar precursor of the small ribosomal subunit. CURRENT OPINION IN STRUCTURAL BIOLOGY. 49: 85-93

Observing the Formation of Ribosomes

Identifying and observing the molecules that form ribosomes — the cellular factories that build the proteins essential for life — has been a key goal for biologists that had seemed nearly unattainable. But a new Scripps Research study, appearing in the October 29, 2010 issue of Science, yielded pictures of the chemical intermediate steps in ribosome creation.  The Scripps lead team developed a new technique, dubbed discovery single-particle profiling, which dodges a previously frustrating purification problem by allowing successful imaging of unpurified samples.