Recommended Readings: Rudolf Jaenisch, M.D. December 12

Friday Lecture Series
Friday, December 12, 2014
3:45 p.m., Caspary Auditorium

Rudolf Jaenisch, M.D.
Professor of Biology,
Massachusetts Institute of Technology
Member,
Whitehead Institute for Biomedical Research

iPS Cell Technology, Gene Editing and Disease Research

Recommended Readings

Empirical Articles

Chung, C. Y., Khurana, V., Auluck, P. K., Tardiff, D. F., Mazzulli, J. R., Soldner, F., … Lindquist, S. (2013). Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science, 342(6161), 983–987. doi:10.1126/science.1245296

Li, Y., Wang, H., Muffat, J., Cheng, A. W., Orlando, D. a, Lovén, J., … Jaenisch, R. (2013). Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell, 13(4), 446–458. doi:10.1016/j.stem.2013.09.001

Soldner, F., Laganière, J., Cheng, A. W., Hockemeyer, D., Gao, Q., Alagappan, R., … Jaenisch, R. (2011). Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell, 146(2), 318–331. doi:10.1016/j.cell.2011.06.019

Wang, H., Yang, H., Shivalila, C. S., Dawlaty, M. M., Cheng, A. W., Zhang, F., & Jaenisch, R. (2013). One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell, 153(4), 910–918. doi:10.1016/j.cell.2013.04.025

Review Papers

Buganim, Y., Faddah, D. A., & Jaenisch, R. (2013). Mechanisms and models of somatic cell reprogramming. Nature Reviews Genetics, 14(6), 427–439. doi:10.1038/nrg3473

Theunissen, T. W., & Jaenisch, R. (2014). Molecular Control of Induced Pluripotency. Cell Stem Cell, 14(6), 720–734. doi:10.1016/j.stem.2014.05.002

Recommended Readings: Huda Zoghbi, M.D.

Friday Lecture Series

Neurodegenerative Diseases: The Dangers of Too Much Protein Stability

Huda Zoghbi, M.D., professor, Baylor College of Medicine;

investigator, Howard Hughes Medical Institute;

director, Jan and Dan Duncan Neurological Research Institute,

Texas Children’s Hospital

December 6, 2013

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Chahrour, M., & Zoghbi, H. Y. (2007). The story of rett syndrome: From clinic to neurobiology. Neuron, 56(3), 422-437

Fernandez-Funez, P., Nino-Rosales, M. L., De Gouyon, B., She, W. -., Luchak, J. M., Martinez, P., . . . Botas, J. (2000). Identification of genes that modify ataxin-1-induced neurodegeneration. Nature, 408(6808), 101-106

Jafar-Nejad, P., Ward, C. S., Richman, R., Orr, H. T., & Zoghbi, H. Y. (2011). Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3ε haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America, 108(5), 2142-2147

Lim, J., Hao, T., Shaw, C., Patel, A. J., Szabó, G., Rual, J. -., . . . Zoghbi, H. Y. (2006). A protein-protein interaction network for human inherited ataxias and disorders of purkinje cell degeneration. Cell, 125(4), 801-814

Riley, B. E., Zoghbi, H. Y., & Orr, H. T. (2005). SUMOylation of the polyglutamine repeat protein, ataxin-1, is dependent on a functional nuclear localization signal. Journal of Biological Chemistry, 280(23), 21942-21948

Zoghbi, H. Y., & Botas, J. (2002). Mouse and fly models of neurodegeneration. Trends in Genetics, 18(9), 463-471

Zoghbi, H. Y., & Warren, S. T. (2010). Neurogenetics: Advancing the “next-generation” of brain research. Neuron, 68(2), 165-173