Recommended Readings: Li Zhao, Ph.D. Monday April 15, 2019

Monday Lectures

Monday, April 15, 2019  4:00 p.m.

Carson Family Auditorium

Li Zhao, Ph.D.

Assistant Professor and Head

Laboratory of Evolutionary Genetics and Genomics

The Rockefeller University

The Origin and Evolution of De Novo Genes


Recommended Readings:

Empirical Articles

Matthews, Benjamin J.; Dudchenko, Olga; Kingan, Sarah B.; et al. (2018). Improved reference genome of Aedes aegypti informs arbovirus vector control. NATURE. 563 (7732): 501-+

Zhao, Li; Begun, David J. (2017). Genomics of parallel adaptation at two timescales in Drosophila. PLOS GENETICS. 13 (10)

Svetec, Nicolas; Cridland, Julie M.; Zhao, Li; et al. (2016). The adaptive significance of natural genetic variation in the DNA damage response of Drosophila melanogaster. PLOS GENETICS. 12 (3)

Li, Xueyan; Fan, Dingding; Zhang, Wei; et al. (2015). Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies. NATURE COMMUNICATIONS. 6

Zhao, Li; Wit, Janneke; Svetec, Nicolas; et al. (2015). Parallel gene expression differences between low and high latitude populations of Drosophila melanogaster and D. simulans. PLOS GENETICS. 11 (5)

Zhao, Li; Saelao, Perot; Jones, Corbin D.; et al. (2014). Origin and spread of de novo genes in Drosophila melanogaster populations. SCIENCE. 343 (6172): 769–772

Ding, Yun; Zhao, Li; Yang, Shuang; et al. (2010). A Young Drosophila Duplicate Gene Plays Essential Roles in Spermatogenesis by Regulating Several Y- Linked Male Fertility Genes. PLOS GENETICS. 6 (12)

Recommended Readings: Daniel Finley, Ph.D. May 30

Friday Lecture Series
Friday, May 30, 2014
3:45 p.m., Caspary Auditorium

Daniel Finley, Ph.D.
Department of Cell Biology
Harvard Medical School

Regulation of Proteasome Activity by Ubiquitin Chain Editing

Recommended Readings:

Empirical Articles

Crosas, B., Hanna, J., Kirkpatrick, D. S., Zhang, D. P., Tone, Y., Hathaway, N. a, … Finley, D. (2006). Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell, 127(7), 1401–1413. doi:10.1016/j.cell.2006.09.051

Hanna, J., Hathaway, N. a, Tone, Y., Crosas, B., Elsasser, S., Kirkpatrick, D. S., … Finley, D. (2006). Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell, 127(1), 99–111. doi:10.1016/j.cell.2006.07.038

Lee, B.-H., Lee, M. J., Park, S., Oh, D.-C., Elsasser, S., Chen, P.-C., … Finley, D. (2010). Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature, 467(7312), 179–184. doi:10.1038/nature09299

Leggett, D. S., Hanna, J., Borodovsky, A., Crosas, B., Schmidt, M., Baker, R. T., … Finley, D. (2002). Multiple associated proteins regulate proteasome structure and function. Molecular Cell, 10(3), 495–507.

Review Papers

Finley, D. (2009). Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome. Annual Review of Biochemistry, 78(1), 477–513. doi:10.1146/annurev.biochem.78.081507.101607

Schmidt, M., & Finley, D. (2014). Regulation of proteasome activity in health and disease. Biochimica et Biophysica Acta, 1843(1), 13–25. doi:10.1016/j.bbamcr.2013.08.012