Recommended Readings: Liangcai Gu, Ph.D. January 7

Special Lecture
Wednesday, January 7, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Liangcai Gu, Ph.D.
Research Fellow,
Department of Genetics,
Harvard Medical School

In Situ Sequencing of Molecular Interactomes

Recommended Readings

Empirical Articles

Gu, L., Li, C., Aach, J., Hill, D. E., Vidal, M., & Church, G. M. (2014). Multiplex single-molecule interaction profiling of DNA-barcoded proteins. Nature, 515(7528), 554–557. doi:10.1038/nature13761

Gu, L., Wang, B., Kulkarni, A., Geders, T. W., Grindberg, R. V, Gerwick, L., … Sherman, D. H. (2009). Metamorphic enzyme assembly in polyketide diversification. Nature, 459(7247), 731–735. doi:10.1038/nature07870

Li, J., Gu, L., Aach, J., & Church, G. M. (2014). Improved cell-free RNA and protein synthesis system. PLOS ONE, 9(9), e106232. doi:10.1371/journal.pone.0106232

Review Papers

Jones, A. C., Gu, L., Sorrels, C. M., Sherman, D. H., & Gerwick, W. H. (2009). New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria. Current Opinion in Chemical Biology, 13(2), 216–23. doi:10.1016/j.cbpa.2009.02.019

Recommended Readings: Thomas W. Muir PhD

Monday Lecture Series

Turning Virulence On and Off in Staphylococci

 Thomas W. Muir, PhD

Richard E Salomon Family Professor and head,

Selma and Lawrence Ruben Laboratory of Synthetic Protein Chemistry

 Welch Hall, Level two   3:45 Refreshments   4:00 Lecture

Related Articles:

Shopsin, Bo; Drlica-Wagner, Elax; Mathema, Barun; Adhikari, Rajan P.; Kreiswirth, Barry N.; Novick, Richard P.   2008.  Prevalence of agr dysfunction among colonizing Staphylococcus aureus.  JOURNAL OF INFECTIOUS DISEASES   198(8): 1171-1174

George, Elizabeth A. and T. W. Muir.  2007.  Molecular mechanisms of agr quorum sensing in virulent staphylococci. CHEMBIOCHEM   8 (8): 847-855 

Wright, J.S.; Lyon, G. J.; George, E. A.; Muir, T. W.; Novick, R. P.   2004.  Hydrophobic interactions drive ligand-receptor recognition for activation and inhibition of staphylococcal quorum sensing.  PNAS  101(46):16168-16173

Muir, T. W.   2003.  Turning virulence on and off in StaphylococciJOURNAL OF PEPTIDE SCIENCE  9(10):612-619

Lyon, G. J.; Wright, J. S.; Muir, T. W. ; Novick, R. P.  2002.  Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus. BIOCHEMISTRY   41(31):10095-10104 

Lyon, G. J.; Mayville, P.; Muir, T. W.; Novick, R. P.  2000.  Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC.   PNAS   97(24): 13330-13335