Recommended Readings: Tom W. Muir, Ph.D.

Friday Lecture Series

A Synthetic “Kiss of Death”

 Tom W. Muir, Ph.D.

Richard E. Salomon Professor and head, Selma and Lawrence Ruben Laboratory of Synthetic Protein Chemistry

The Rockefeller University

March 6, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Alexeev, D., P. N. Barlow, S. M. Bury, J. -D Charrier, A. Cooper, D. Hadfield, C. Jamieson, et al. 2003. Synthesis, structural and biological studies of ubiquitin mutants containing (2S, 4S)-5-fluoroleucine residues strategically placed in the hydrophobic core. ChemBioChem. 4(9):894-896.

 

Alexeev, D., S. M. Bury, M. A. Turner, O. M. Ogunjobi, T. W. Muir, R. Ramage, and L. Sawyer. 1994. Synthetic, structural and biological studies of the ubiquitin system: Chemically synthesized and native ubiquitin fold into identical three-dimensional structures. Biochemical Journal. 299(1):159-163.

 

Chatterjee, C., R. K. McGinty, J. -P Pellois, and T. W. Muir. 2007. Auxiliary-mediated site-specific peptide ubiquitylation. Angewandte Chemie – International Edition. 46(16):2814-2818.

 

Chiang, K. P., and T. W. Muir. 2008. Systems- and molecular-level elucidation of signaling processes through chemistry. Science signaling. 1(42):pp. pe45.

 

Layfield, R., K. Franklin, M. Landon, G. Walker, P. Wang, R. Ramage, A. Brown, et al. 1999. Chemically synthesized ubiquitin extension proteins detect distinct catalytic capacities of deubiquitinating enzymes. Analytical Biochemistry. 274(1):40-49.

 

Love, S. G., T. W. Muir, R. Ramage, K. T. Shaw, D. Alexeev, L. Sawyer, S. M. Kelly, et al. 1997. Synthetic, structural and biological studies of the ubiquitin system: Synthesis and crystal structure of an analogue containing unnatural amino acids. Biochemical Journal. 323(3):727-734.

 

McGinty, R. K., J. Kim, C. Chatterjee, R. G. Roeder, and T. W. Muir. 2008. Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature. 453(7196):812-816.

 

Ramage, R., J. Green, T. W. Muir, O. M. Ogunjobi, S. Love, and K. Shaw. 1994. Synthetic, structural and biological studies of the ubiquitin system: The total chemical synthesis of ubiquitin. Biochemical Journal. 299(1):151-158.