Recommended Readings: Ying Lu, Ph.D., February 29

Special Lecture Series
Monday, February 29
4:00 p.m., Carson Family Auditorium (CRC)

Ying Lu, Ph.D.,
Postdoctoral Fellow,
Department of Systems Biology,
Harvard Medical School

Specificity, Efficiency and Processivity in the Eukaryotic Protein Degradation System

Recommended Readings

Lu, Y., Lee, B. H., King, R. W., Finley, D., & Kirschner, M. W. (2015). Substrate degradation by the proteasome: A single-molecule kinetic analysis. Science, 348(6231), 1250834. doi: 10.1126/science.1250834.

Lu, Y., Wang, W., & Kirschner, M. W. (2015). Specificity of the anaphase-promoting complex: A single-molecule study. Science, 348(6231), 1248737. doi: 10.1126/science.1248737

Recommended Readings: Hani S. Zaher, PH.D. Monday, March 5, 2012

Dealing with Mistakes: a New Form of Proofreading on the Ribosome

Hani S. Zaher, Ph.D

Postdoctoral Fellow

Department of Molecular Biology and Genetics

Johns Hopkins School of Medicine

4:00 p.m.  Monday, March 5, 2012   Refreshments at 3:45

Caspary Auditorium

Recommended Readings:

Zaher HS; Shaw JJ; Strobel SA; et al.  2011.  The 2’-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTCEMBO Journal.   30(12):2445-2453.   DOI:10.1038/emboj.2011.142

Zaher HS; Green R.  2011.  A primary role for release factor 3 in quality control during translation eloncation in Escherichia coli.  CELL.  147(2):396-408.   DOI:10.1016/j.cell.2011.08.45

Zaher HS; Green R.  2010.  Kinetic basis for global loss of fidelity arising from mismatches in the P-site codon:anticodon helix.   RNA-A Publication of the RNA Society.  16(10):1980-1989.  DOI:10.1261/rna.2241810.

Zaher HS; Green R.  2010.  Hyperaccurate and error-prone ribosomes exploit distinct mechanisms during tRFNA selectionMolecular Cell   39(1):110-120.   DOI:10.1016/j.molcel.2010.06.009

Zaher HS; Green R. 2009.  Fidelity at the molecular level: lessons from protein synthesis.   CELL.  136(4):746-762.  DOI:10.1016/j.cell.2009.01.036

Zaher HS; Green R.  2009.  Quality control by the ribosome following peptide bond formation.  NATURE.  457(7226):161-U51.   DOI:10.1038/nature07582