Recommended Readings: Juleen R. Zierath, Ph.D.

Friday Lecture Series

Nicholson Lecture

Molecular Mechanisms for the Health-promoting Effects of Exercise: Why Muscle Matters!

Juleen R. Zierath, Ph.D., professor of physiology, department of molecular

medicine and surgery, Section for Integrative Physiology, Karolinska Institutet;

professor of integrative physiology and scientific director,

Novo Nordisk Foundation Center for Basic Metabolic Research,

Copenhagen University

October 25, 2013

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Barrès, R., Yan, J., Egan, B., Treebak, J. T., Rasmussen, M., Fritz, T., . . . Zierath, J. R. (2012). Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metabolism, 15(3), 405-411

Cantó, C., Jiang, L. Q., Deshmukh, A. S., Mataki, C., Coste, A., Lagouge, M., . . . Auwerx, J. (2010). Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metabolism, 11(3), 213-219

Egan, B., Carson, B. P., Garcia-Roves, P. M., Chibalin, A. V., Sarsfield, F. M., Barron, N., . . . O’Gorman, D. J. (2010). Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor γ coactivator-1α mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle. Journal of Physiology, 588(10), 1779-1790

Egan, B., O’Connor, P. L., Zierath, J. R., & O’Gorman, D. J. (2013). Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle. PLoS ONE, 8(9)

Egan, B., & Zierath, J. R. (2013). Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metabolism, 17(2), 162-184

Russell, A. P., Lamon, S., Boon, H., Wada, S., Güller, I., Brown, E. L., . . . Akimoto, T. (2013). Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training. Journal of Physiology, 591(18), 4637-4653

Szekeres, F., Chadt, A., Tom, R. Z., Deshmukh, A. S., Chibalin, A. V., Björnholm, M., . . . Zierath, J. R. (2012). The rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism. American Journal of Physiology – Endocrinology and Metabolism, 303(4), E524-E533


UCLA Team Builds Microfluidic Platform for Measuring Protein Kinase Activity

University of California, Los Angeles, researchers have built an integrated chip-based microfluidic and imaging platform capable of measuring kinase activity in samples containing as few as 3,000 cells.

The platform, which the scientists used to measure ABL kinase activity – the target of the kinase inhibitor Gleevec – in BCR-ABL-positive leukemia patient samples, could potentially be expanded into a multiplex version for use in high-throughput kinase studies, said Thomas Graeber, assistant professor of molecular and medical pharmacology at UCLA and one of the platform’s developers.  Read more here.