Recommended Readings: Denes Hnisz, Ph.D., October 12th

Special Lecture
Monday, October 12th, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Denes Hnisz, Ph.D.
Postdoctoral Fellow,
Whitehead Institute for Biomedical Research

Transcriptional Regulatory Mechanisms Defining Cell Identity

Recommended Readings

Dowen, J. M., Fan, Z. P., Hnisz, D., Ren, G., Abraham, B. J., Zhang, L. N., … & Young, R. A. (2014). Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes. Cell, 159(2), 374-387. doi:10.1016/j.cell.2014.09.030.

Hnisz, D., Abraham, B. J., Lee, T. I., Lau, A., Saint-André, V., Sigova, A. A., … & Young, R. A. (2013). Super-enhancers in the control of cell identity and disease. Cell, 155(4), 934-947. doi:10.1016/j.cell.2013.09.053.

Hnisz, D., Schuijers, J., Lin, C. Y., Weintraub, A. S., Abraham, B. J., Lee, T. I., … & Young, R. A. (2015). Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers. Molecular Cell, 58(2), 362-370. doi:10.1016/j.molcel.2015.02.014.

Whyte, W. A., Orlando, D. A., Hnisz, D., Abraham, B. J., Lin, C. Y., Kagey, M. H., … & Young, R. A. (2013). Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell, 153(2), 307-319. doi:10.1016/j.cell.2013.03.035.

Recommended Readings: Martin Kampmann Ph.D. Monday, January 27

SPECIAL SEMINAR
Monday, January 27, 2014
4:00 p.m., Carson Family Auditorium

Martin Kampmann, Ph.D.
Postdoctoral Scholar
University of San Francisco

Toward a Systematic Understanding of the Mammalian Proteostasis Network and its Therapeutic Potential

Recommended Readings:

Empirical Papers

Bassik, M. C., Kampmann, M., Lebbink, R. J., Wang, S., Hein, M. Y., Poser, I., … Weissman, J. S. (2013). A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell, 152(4), 909–922. doi:10.1016/j.cell.2013.01.030

Kampmann, M., Bassik, M. C., & Weissman, J. S. (2013). Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America, 110(25), E2317–2326. doi:10.1073/pnas.1307002110

Review Articles

Balch, W. E., Morimoto, R. I., Dillin, A., & Kelly, J. W. (2008). Adapting proteostasis for disease intervention. Science, 319(5865), 916–919. doi:10.1126/science.1141448

Hartl, F. U., Bracher, A., & Hayer-Hartl, M. (2011). Molecular chaperones in protein folding and proteostasis. Nature, 475(7356), 324–332. doi:10.1038/nature10317

Foldit – Play A Video Game, Contribute To Medical Science

A new game, named Foldit, turns protein folding into a competitive sport. Introductory levels teach the rules, which are the same laws of physics by which protein strands curl and twist into three-dimensional shapes – key for biological mysteries ranging from Alzheimer’s to vaccines.

After about 20 minutes of training, people feel like they’re playing a video game but are actually mouse-clicking in the name of medical science.

Recommended Readings: Arthur Horwich, M.D.; April 24

Friday Lecture Series

“Chaperone Machines and Involvement in a Form of ALS”

Weisbach Memorial Lecture

Arthur Horwich, M.D.

Yale University

April 24, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Bukau, B., J. Weissman, and A. Horwich. 2006. Molecular chaperones and protein quality control. Cell. 125(3):443-451.

 

Wang, J., G. W. Farr, D. H. Hall, F. Li, K. Furtak, L. Dreier, and A. L. Horwich. 2009. An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans. PLoS Genetics. 5(1), art. no. e1000350.

 

Wang, J., G. W. Farr, C. J. Zeiss, D. J. Rodriguez-Gil, J. H. Wilson, K. Furtak, D. T. Rutkowski, et al. 2009. Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Proceedings of the National Academy of Sciences of the United States of America. 106(5):1392-1397.

 

Grantcharova, V., E. J. Alm, D. Baker, and A. L. Horwich. 2001. Mechanisms of protein folding. Current opinion in structural biology. 11(1): 70-82.

 

Horwich, A. L., Fenton, W. A., Chapman, E., and Farr, G. W. 2007.  Two families of chaperonin: Physiology and mechanism. Annual Review of Cell and Developmental Biology. 23:115-145 .