Insight: Huge Molecular Machine that Disposes of Undesirable Proteins

ScienceDaily (Aug. 2, 2010) — Scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory have obtained the closest look yet of how a gargantuan molecular machine breaks down unwanted proteins in cells, a critical housekeeping chore that helps prevent diseases such as cancer.  They pieced together the molecular-scale changes the machine undergoes as it springs into action, ready to snip apart a protein. Their work provides valuable clues as to how the molecular machine, a giant enzyme called tripeptidyl peptidase II, keeps cells tidy and disease free. It could also inform the development of obesity-fighting drugs.  Read more in Nature Structural and Molecular Biology.

Related Readings – Sidney Strickland Ph.D.

Proteases, the Extracellular Matrix and Cell Death: lessons from the overexcited brain

Monday, April 28, 2008 Welch Hall (2nd floor)

3:45 pm. Refreshments 4:00 p.m. Lecture


Recommended Review Article:

Kaul M, Lipton SA. (2005) Experimental and potential future therapeutic approaches for HIV-1 associated dementia targeting receptors for chemokines, glutamate and erythropoietin. Neurotoxicity Research 276(20): 16593-16596

Related Articles:

Lee, S.R.; Lok, J.; Rosell, A. et al. (2007) Reduction of hippocampal cell death and proteolytic responses in tissue plasminogen activator knockout mice after transient global cerebral ischemia. Neuroscience 150(1): 50-57

Chu K, Lee ST, Sinn DI, et al. (2007) Pharmacological induction of ischemic tolerance by glutamate transporter-1 (EAAT2) upregulation. Stroke 38(1):177-182

Penkowa M, Florit S, Giralt M, et al. (2005) Metallothionein reduces central nervous system inflammation, neuro degeneration, and cell death following kainic acid-induced epileptic seizures Journal of Neuroscience Research 79(4):522-534

Kaur J, Zhao ZG, Klein GM, et al. (2004) The neurotoxicity of tissue plasminogen activator? Journal of Cerebral Blood Flow and Metabolism 24(9): 945-963

Finlay M, Clements JM, et al. (2004) Reduction of excitotoxicity and associated leukocyte recruitment by a broad-spectrum matrix metalloproteinase inhibitor Journal of Neurochemistry  89(6): 1378-1386

Swanson, R. A.; Ying, W.; Kaupinnen, T.M. (2004) Astrocyte influences on ischemic neuronal death Current Molecular Medicine 4(2):193-205