Recommended Readings: Daniel Finley, Ph.D. May 30

Friday Lecture Series
Friday, May 30, 2014
3:45 p.m., Caspary Auditorium

Daniel Finley, Ph.D.
Department of Cell Biology
Harvard Medical School

Regulation of Proteasome Activity by Ubiquitin Chain Editing

Recommended Readings:

Empirical Articles

Crosas, B., Hanna, J., Kirkpatrick, D. S., Zhang, D. P., Tone, Y., Hathaway, N. a, … Finley, D. (2006). Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell, 127(7), 1401–1413. doi:10.1016/j.cell.2006.09.051

Hanna, J., Hathaway, N. a, Tone, Y., Crosas, B., Elsasser, S., Kirkpatrick, D. S., … Finley, D. (2006). Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell, 127(1), 99–111. doi:10.1016/j.cell.2006.07.038

Lee, B.-H., Lee, M. J., Park, S., Oh, D.-C., Elsasser, S., Chen, P.-C., … Finley, D. (2010). Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature, 467(7312), 179–184. doi:10.1038/nature09299

Leggett, D. S., Hanna, J., Borodovsky, A., Crosas, B., Schmidt, M., Baker, R. T., … Finley, D. (2002). Multiple associated proteins regulate proteasome structure and function. Molecular Cell, 10(3), 495–507.

Review Papers

Finley, D. (2009). Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome. Annual Review of Biochemistry, 78(1), 477–513. doi:10.1146/annurev.biochem.78.081507.101607

Schmidt, M., & Finley, D. (2014). Regulation of proteasome activity in health and disease. Biochimica et Biophysica Acta, 1843(1), 13–25. doi:10.1016/j.bbamcr.2013.08.012