Recommended Readings: Paul Cohen, M.D., Ph.D., April 25

Monday Lecture Series
Monday, April 25, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Paul Cohen, M.D., Ph.D.
Albert Resnick, M.D., Assistant Professor and Head,
Laboratory of Molecular Metabolism,
The Rockefeller University

Molecular Regulation of Fat Cell Phenotype

Recommended Readings

Chi, J., & Cohen, P. (2016). The multifaceted roles of PRDM16: Adipose biology and beyond. Trends in Endocrinology & Metabolism, 27(1), 11-23. doi:10.1016/j.tem.2015.11.005

Cohen, P., Levy, J. D., Zhang, Y., Frontini, A., Kolodin, D. P., Svensson, K. J., … & Wu, J. (2014). Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell, 156(1), 304-316. doi:10.1016/j.cell.2013.12.021

Cohen, P., & Spiegelman, B. M. (2015). Brown and beige fat: molecular parts of a thermogenic machine. Diabetes, 64(7), 2346-2351. doi: 10.2337/db15-0318

Kir, S., White, J. P., Kleiner, S., Kazak, L., Cohen, P., Baracos, V. E., & Spiegelman, B. M. (2014). Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature, 513(7516), 100-104. doi:10.1038/nature13528

Recommended Readings: Paul Cohen, M.D., Ph.D. June 24

Special Seminar 
Tuesday, June 24, 2014
4:00 p.m., Carson Family Auditorium

Paul Cohen, M.D., Ph.D.
Postdoctoral Fellow, Dana Farber Cancer Institute
Attending Cardiologist, Brigham and Women’s Hospital
Instructor in Medicine, Harvard Medical School

Transcriptional Determinants of Subcutaneous and Visceral Adipose Tissue: Towards Engineering Healthier Fat

Recommended Readings:

Empirical Articles

Cohen, P., Levy, J. D., Zhang, Y., Frontini, A., Kolodin, D. P., Svensson, K. J., … Spiegelman, B. M. (2014). Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell, 156(1-2), 304–16. doi:10.1016/j.cell.2013.12.021

Seale, P., Conroe, H. M., Estall, J., Kajimura, S., Frontini, A., Ishibashi, J., … Spiegelman, B. M. (2011). Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. The Journal of Clinical Investigation, 121(1), 53–56. doi:10.1172/JCI44271.96

Review Papers

Wu, J., Cohen, P., & Spiegelman, B. M. (2013). Adaptive thermogenesis in adipocytes: is beige the new brown? Genes & Development, 27(3), 234–50. doi:10.1101/gad.211649.112

Recommended Readings: Patrick Seale, Ph.D.

Monday Lecture Series (note: held on Tuesday 2.17.09)

The Transcriptional Regulator PRDM16 Controls a Brown Fat/Skeletal Muscle Development Switch

Patrick Seale, Ph.D.

Post-doctoral Research Fellow, Department of Cancer Biology

Dana-Farber Cancer Institute and Harvard Medical School

Tuesday, February 17, 2009

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Cannon, B., and J. Nedergaard. 2008. Developmental biology: Neither fat nor flesh. Nature. 454(7207):947-948.

Cooper, M. P., M. Uldry, S. Kajimura, Z. Arany, and B. M. Spiegelman. 2008. Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130. Journal of Biological Chemistry. 283(46):31960-31967.

Kajimura, S., P. Seale, T. Tomaru, H. Erdjument-Bromage, M. P. Cooper, J. L. Ruas, S. Chin, P. Tempst, M. A. Lazar, and B. M. Spiegelman. 2008. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes and Development. 22(10):1397-1409.

Lazar, M. A. 2008. Developmental biology: How now, brown fat? Science. 321(5892):1048-1049.

Seale, P., B. Bjork, W. Yang, S. Kajimura, S. Chin, S. Kuang, A. Scimè, et al. 2008. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 454(7207):961-967.

Seale, P., S. Kajimura, W. Yang, S. Chin, L. M. Rohas, M. Uldry, G. Tavernier, D. Langin, and B. M. Spiegelman. 2007. Transcriptional control of brown fat determination by PRDM16. Cell Metabolism. 6(1):38-54.

 Uldry, M., W. Yang, J. St-Pierre, J. Lin, P. Seale, and B. M. Spiegelman. 2006. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metabolism. 4(1):97.