Recommended Readings: Mitchell Guttman; March 25, 2009

Special Seminar Series

Large Intergenic ncRNAs in the Mammalian Genome:

From Discovery to Mechanism

Mitchell Guttman

Graduate fellow, Department of Biology

Broad Institute of MIT and Harvard/Massachusetts Institute of Technology

Wednesday, March 25, 2009

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Guttman, M., I. Amit, M. Garber, C. French, M. F. Lin, D. Feldser, M. Huarte, et al. 2009. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature, in press.

Guttman, M., C. Mies, K. Dudycz-Sulicz, S. J. Diskin, D. A. Baldwin, C. J. Stoeckert Jr., and G. R. Grant. 2007. Assessing the significance of conserved genomic aberrations using high resolution genomic microarrays. PLoS Genetics. 3(8)e143.

Clamp, M., B. Fry, M. Kamal, X. Xie, J. Cuff, M. F. Lin, M. Kellis, K. Lindblad-Toh, and E. S. Lander. 2007. Distinguishing protein-coding and noncoding genes in the human genome. Proceedings of the National Academy of Sciences of the United States of America. 104(49):19428-19433.

Willingham, A. T., A. P. Orth, S. Batalov, E. C. Peters, B. G. Wen, P. Aza-Blanc, J. B. Hogenesch, and P. G. Schultz. 2005. Molecular biology: A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. Science. 309(5740):1570-1573.

Rinn, J. L., M. Kertesz, J. K. Wang, S. L. Squazzo, X. Xu, S. A. Brugmann, L. H. Goodnough, et al. 2007. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell. 129(7):1311-1323.

Ponjavic, J., C. P. Ponting, and G. Lunter. 2007. Functionality or transcriptional noise? evidence for selection within long noncoding RNAs. Genome Research. 17(5):556-565.