Recommended Readings: Marc Tessier-Lavigne, Ph.D., April 6

Monday Lecture Series
Monday, April 6, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Marc Tessier-Lavigne, Ph.D.,
Carson Family Professor and Head,
Laboratory of Brain Development and Repair,
The Rockefeller University

Sculpting Neuronal Connections: The Logic and Mechanisms of Axon Growth and Pruning

Recommended Readings

Empirical Articles

Leyva-Díaz, E., del Toro, D., Menal, M. J., Cambray, S., Susín, R., Tessier-Lavigne, M., … & López-Bendito, G. (2014). FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons. Current Biology, 24(5), 494-508. doi:10.1016/j.cub.2014.01.042

Mire, E., Mezzera, C., Leyva-Díaz, E., Paternain, A. V., Squarzoni, P., Bluy, L., … & López-Bendito, G. (2012). Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth. Nature Neuroscience, 15(8), 1134-1143. doi:10.1038/nn.3160

Romi, E., Gokhman, I., Wong, E., Antonovsky, N., Ludwig, A., Sagi, I., … & Yaron, A. (2014). ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A. Nature communications, 5. doi:10.1038/ncomms5058

Xu, K., Wu, Z., Renier, N., Antipenko, A., Tzvetkova-Robev, D., Xu, Y., … & Nikolov, D. B. (2014). Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. Science, 344(6189), 1275-1279. doi:10.1126/science.1255149

Review Papers

Kolodkin, A. L., & Tessier-Lavigne, M. (2011). Mechanisms and molecules of neuronal wiring: a primer. Cold Spring Harbor Perspectives in Biology, 3(6), a001727. doi:10.1101/cshperspect.a001727

Recommended Readings: Thomas Südhof, M.D. December 5

Friday Lecture Series
Friday, December 5, 2014
3:45 p.m., Caspary Auditorium

Thomas Südhof, M.D.
Avram Goldstein Professor,
Department of Molecular and Cellular Physiology,
Stanford School of Medicine
Howard Hughes Medical Institute

Cracking the Neurexin Code – Towards a Molecular Logic of Neural Circuits

Recommended Readings

Empirical Articles

Gokce, O., & Südhof, T. C. (2013). Membrane-tethered monomeric neurexin LNS-domain triggers synapse formation. The Journal of Neuroscience, 33(36), 14617–14628. doi:10.1523/JNEUROSCI.1232-13.2013

Rothwell, P. E., Fuccillo, M. V, Maxeiner, S., Hayton, S. J., Gokce, O., Lim, B. K., … Südhof, T. C. (2014). Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors. Cell, 158(1), 198–212. doi:10.1016/j.cell.2014.04.045

Treutlein, B., Gokce, O., Quake, S. R., & Südhof, T. C. (2014). Cartography of neurexin alternative splicing mapped by single-molecule long-read mRNA sequencing. Proceedings of the National Academy of Sciences, 111(13), E1291–E1299. doi:10.1073/pnas.1403244111

Tsetsenis, T., Boucard, a. a., Arac, D., Brunger, a. T., & Sudhof, T. C. (2014). Direct visualization of trans-synaptic neurexin-neuroligin interactions during synapse formation. Journal of Neuroscience, 34(45), 15083–15096. doi:10.1523/JNEUROSCI.0348-14.2014

Review Articles

Südhof, T. C. (2008). Neuroligins and neurexins link synaptic function to cognitive disease. Nature, 455(7215), 903–911. doi:10.1038/nature07456

Südhof, T. C. (2014). The molecular machinery of neurotransmitter release (Nobel Lecture). Angewandte Chemie, 53(47), 12696–12717. doi:10.1002/anie.201406359