Yale Scientists Develop Synthetic Biology Approach for Generating Phosphoproteins

Yale researchers have devised a technique for expressing activated phosphoproteins in Escherichia coli, using it to generate phosphorylated versions of the protein MEK1, a key molecule in cell proliferation, development, differentiation, and oncogenesis. 

According to Yale assistant professor Jesse Rinehart, one of the leaders of the study – which was published in Science – the technique could prove an important source of reagents for phosphoproteomic research and provides an early glimpse of synthetic biology’s potential to aid proteomics more generally.