Recommended Readings: Richard Lifton, M.D., Ph.D.

Friday Lecture Series

Rufus Cole Lecture

Genes, Genomes and the Future of Medicine

Richard Lifton, M.D., Ph.D.,director, Yale Center for Human Genetics and

Genomics,chair, department of genetics and Sterling Professor of Genetics and

Internal Medicine, Yale University School of Medicine;

investigator, Howard Hughes Medical Institute

June 1, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Reading

Choi, M., U. I. Scholl, W. Ji, T. Liu, I. R. Tikhonova, P. Zumbo, A. Nayir, et al. 2009. Genetic Diagnosis by Whole Exome Capture and Massively Parallel DNA Sequencing. Proceedings of the National Academy of Sciences of the United States of America 106 (45): 19096-19101

Choi, M., U. I. Scholl, P. Yue, P. Björklund, B. Zhao, C. Nelson-Williams, W. Ji, et al. 2011. K + Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension. Science 331 (6018): 768-772

Ji, W., J. N. Foo, B. J. O’Roak, H. Zhao, M. G. Larson, D. B. Simon, C. Newton-Cheh, M. W. State, D. Levy, and R. P. Lifton. 2008. Rare Independent Mutations in Renal Salt Handling Genes Contribute to Blood Pressure Variation. Nature Genetics 40 (5): 592-599

Lifton, R. P. 2010. Individual Genomes on the Horizon. New England Journal of Medicine 362 (13): 1235-1236

Lo, S. M., M. Choi, J. Liu, D. Jain, R. G. Boot, W. W. Kallemeijn, J. M. F. G. Aerts, et al. 2012. Phenotype Diversity in Type 1 Gaucher Disease: Discovering the Genetic Basis of Gaucher disease/hematologic Malignancy Phenotype by Individual Genome Analysis. Blood 119 (20): 4731-4740

Monette, M. Y., J. Rinehart, R. P. Lifton, and B. Forbush. 2011. Rare Mutations in the Human NA-K-CL Cotransporter (NKCC2) Associated with Lower Blood Pressure Exhibit Impaired Processing and Transport Function. American Journal of Physiology – Renal Physiology 300 (4): 840-847

Scholl, U. I., M. Choi, T. Liu, V. T. Ramaekers, M. G. Häusler, J. Grimmer, S. W. Tobe, A. Farhi, C. Nelson-Williams, and R. P. Lifton. 2009. Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, and Electrolyte Imbalance (SeSAME Syndrome) Caused by Mutations in KCNJ10. Proceedings of the National Academy of Sciences of the United States of America 106 (14): 5842-5847



Related Readings – David L. Stern, PhD

Special Seminar Series: Evolution, Ecology and Ethology

Dissecting the Genetic Causes of Morphological Differences Between Fly Species

Welch Hall Level 2 Wednesday February 6 4 p.m.

Recommended Review Article:

Frankino, W.A.; Zwaan, B.J.; Stern, D.L. and Brakefield, P.M. (2005) Natural selection and developmental constraints in the evolution of allometries. Science 307 (5710):718-720

Related Articles:

Orgogozo, V.; Muro, N.M.; Stern, D.L. (2007) Variation in fiber number of a male-specific muscle between Drosophila species: a genetic and developmental analysis. Evolution & Development 9 (4):368-377

McGregor, A. P.; Orgogozo, V.; Delon, I.; Zanet, J.; Srinivasen, D. G.; Payre, F.; Stern, D. L. (2007) Morphological evolution through multiple cis-regulatory mutations on a single gene. Nature 448 (7153):587-590

Kheradpour, P.; Stark, A.; Roy, S.; and Kellis, M. (2007) Reliable prediction of regulator targets using 12 Drosophila genomes. Genome Research 17 (12):1919-1931

Orgogozo, V.; Broman, K. W.; Stern, D. L. (2006) High-resolution quantitative trait locus mapping reveals epistasis controlling ovariole number between two Drosophila species. Genetics 173 (1) :197-205

Orgogozo, V.; Grueber, W.B. (2005) FlyPNS, a database of the Drosophila embryonic and larval peripheral nervous system. BMC Developmental Biology 5 (article 4)