Recommended Readings: Hidde Ploegh, Ph.D.

Friday Lecture Series

Host-pathogen Interactions: A Biochemist’s Perspective

Hidde Ploegh, Ph.D., professor of biology and member,

Whitehead Institute for Biomedical Research

March 28, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Carette, J. E., Guimaraes, C. P., Varadarajan, M., Park, A. S., Wuethrich, I., Godarova, A., . . . Brummelkamp, T. R. (2009). Haploid genetic screens in human cells identify host factors used by pathogens. Science, 326(5957), 1231-1235

Dougan, S. K., Hu, C. -. A., Paquet, M. -., Greenblatt, M. B., Kim, J., Lilley, B. N., . . . Ploegh, H. L. (2011). Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Molecular and Cellular Biology, 31(6), 1145-1159

Loureiro, J., & Ploegh, H. L. (2006). Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions. Advances in Immunology, 92, 225-305

Reiling, J. H., Olive, A. J., Sanyal, S., Carette, J. E., Brummelkamp, T. R., Ploegh, H. L., . . . Sabatini, D. M. (2013). A CREB3-ARF4 signalling pathway mediates the response to golgi stress and susceptibility to pathogens. Nature Cell Biology, 15(12), 1473-1485

Tafesse, F. G., Sanyal, S., Ashour, J., Guimaraes, C. P., Hermansson, M., Somerharju, P., & Ploegh, H. L. (2013). Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins. Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6406-6411

Vyas, J. M., Van Der Veen, A. G., & Ploegh, H. L. (2008). The known unknowns of antigen processing and presentation. Nature Reviews Immunology, 8(8), 607-618


Recommended Readings: Michael Strand, Ph.D.

Friday Lecture Series

Polydnaviruses: Viral Mutualists and Nature’s Genetic Engineers

Michael Strand, Ph.D., Regents Professor, department of entomology,

University of Georgia

February 21, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Beck, M. H., & Strand, M. R. (2007). A novel polydnavirus protein inhibits the insect prophenoloxidase activation pathway. Proceedings of the National Academy of Sciences of the United States of America, 104(49), 19267-19272

Burke, G. R., Thomas, S. A., Eum, J. H., & Strand, M. R. (2013). Mutualistic polydnaviruses share essential replication gene functions with pathogenic ancestors. PLoS Pathogens, 9(5)

Strand, M. R., & Burke, G. R. (2012). Polydnaviruses as symbionts and gene delivery systems. PLoS Pathogens, 8(7), 5

Thoetkiattikul, H., Beck, M. H., & Strand, M. R. (2005). Inhibitor κB-like proteins from a polydnavirus inhibit NF-κB activation and suppress the insect immune response. Proceedings of the National Academy of Sciences of the United States of America, 102(32), 11426-11431

Webb, B. A., Strand, M. R., Dickey, S. E., Beck, M. H., Hilgarth, R. S., Barney, W. E., . . . Witherell, R. A. (2006). Polydnavirus genomes reflect their dual roles as mutualists and pathogens. Virology, 347(1), 160-174


Recommended Readings: Kevan Shokat, Ph.D.

Friday Lecture Series

The William H. Stein Memorial Lecture

A New Druggable Pocket on K-Ras and a Neo-substrate for Activating the Kinase

PINK in Parkinson’s Disease

Kevan Shokat, Ph.D., professor and chair, department of cellular and molecular

pharmacology, University of California, San Francisco;

investigator, Howard Hughes Medical Institute

November 22, 2013

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Hertz, N. T., Berthet, A., Sos, M. L., Thorn, K. S., Burlingame, A. L., Nakamura, K., & Shokat, K. M. (2013). A neo-substrate that amplifies catalytic activity of parkinson’s-disease- related kinase PINK1. Cell, 154(4), 737-747

Larochelle, S., Amat, R., Glover-Cutter, K., Sansó, M., Zhang, C., Allen, J. J., . . . Fisher, R. P. (2012). Cyclin-dependent kinase control of the initiation-to-elongation switch of polymerase II. Nature Structural and Molecular Biology, 19(11), 1108-1115

Soskis, M. J., Ho, H. -. H., Bloodgood, B. L., Robichaux, M. A., Malik, A. N., Ataman, B., . . . Greenberg, M. E. (2012). A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nature Neuroscience, 15(12), 1645-1654

Statsuk, A. V., & Shokat, K. M. (2012). Covalent cross-linking of kinases with their corresponding peptide substrates. Methods in Molecular Biology 795 , pp. 179-190

Sun, Y., Miao, Y., Yamane, Y., Zhang, C., Shokat, K. M., Takematsu, H., . . . Drubin, D. G. (2012). Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the pkh-ypk and Cdc55-PP2A pathways. Molecular Biology of the Cell, 23(12), 2388-2398

Ultanir, S., Hertz, N., Li, G., Ge, W. -., Burlingame, A., Pleasure, S., . . . Jan, Y. -. (2012). Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 uncovers their roles in dendrite arborization and spine development. Neuron, 73(6), 1127-1142


Recommended Readings: Hironori Funabiki, Ph.D.

Friday Lecture Series

Spindle or Envelope: Building Right on Chromosomes in Mitosis

Hironori Funabiki, Ph.D.,

associate professor, Laboratory of Chromosome and Cell Biology,

The Rockefeller University

October 4, 2013

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Carmena, M., Wheelock, M., Funabiki, H., & Earnshaw, W. C. (2012). The chromosomal passenger complex (CPC): From easy rider to the godfather of mitosis. Nature Reviews Molecular Cell Biology, 13(12), 789-803

Funabiki, H., & Murray, A. W. (2000). The xenopus chromokinesin xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement. Cell, 102(4), 411-424

Kelly, A. E., Ghenoiu, C., Xue, J. Z., Zierhut, C., Kimura, H., & Funabiki, H. (2010). Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase aurora B. Science, 330(6001), 235-239

Rivera, T., Ghenoiu, C., Rodríguez-Corsino, M., Mochida, S., Funabiki, H., & Losada, A. (2012). Xenopus shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex. EMBO Journal, 31(6), 1467-1479

Sampath, S. C., Ohi, R., Leismann, O., Salic, A., Pozniakovski, A., & Funabiki, H. (2004). The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell, 118(2), 187-202

Tseng, B. S., Tan, L., Kapoor, T. M., & Funabiki, H. (2010). Dual detection of chromosomes and microtubules by the chromosomal passenger complex drives spindle assembly. Developmental Cell, 18(6), 903-91