Recommended Readings: Jorge E. Galán, Ph.D., DVM, February 6

Friday Lecture Series
Friday, February 6, 2015
3:45 p.m., Caspary Auditorium

Jorge E. Galán, Ph.D., DVM
Lucille P. Markey Professor of Microbial Pathogenesis,
Professor of Cell Biology,
Chair, Department of Microbial Pathogenesis,
Yale University School of Medicine

Typhoid fever: new insight into the pathogenesis of an old disease

Recommended Readings

Empirical Articles

Lefebre, M. D., & Galán, J. E. (2014). The inner rod protein controls substrate switching and needle length in a Salmonella type III secretion system. Proceedings of the National Academy of Sciences, 111(2), 817–822. doi:10.1073/pnas.1319698111

Song, J., Gao, X., & Galán, J. E. (2013). Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin. Nature, 499(7458), 350–354. doi:10.1038/nature12377

Spanò, S., & Galán, J. E. (2012). A Rab32-dependent pathway contributes to Salmonella typhi host restriction. Science, 338(6109), 960–963. doi:10.1126/science.1229224

Review Papers

Hicks, S. W., & Galán, J. E. (2013). Exploitation of eukaryotic subcellular targeting mechanisms by bacterial effectors. Nature Reviews Microbiology, 11(5), 316–326. doi:10.1038/nrmicro3009

Recommended Readings: John Mekalanos, Ph.D. October 10

Friday Lecture Series
Friday, October 10, 2014
3:45 p.m., Caspary Auditorium

John Mekalanos, Ph.D.
Adele H. Lehman Professor of Microbiology
Chair, Department of Microbiology and Immunobiology,
Harvard Medical School

The Ghost in the Machine: Understanding Bacterial Secretion Systems Through Defining Their Effectors

Recommended Readings

Empirical Articles

Basler, M., Ho, B. T., & Mekalanos, J. J. (2013). Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions. Cell, 152(4), 884–894. doi:10.1016/j.cell.2013.01.042

Basler, M., Pilhofer, M., Henderson, G. P., Jensen, G. J., & Mekalanos, J. J. (2012). Type VI secretion requires a dynamic contractile phage tail-like structure. Nature, 483(7388), 182–186. doi:10.1038/nature10846

Ma, A. T., McAuley, S., Pukatzki, S., & Mekalanos, J. J. (2009). Translocation of a Vibrio cholerae type VI secretion effector requires bacterial endocytosis by host cells. Cell Host & Microbe, 5(3), 234–243. doi:10.1016/j.chom.2009.02.005

Ma, A. T., & Mekalanos, J. J. (2010). In vivo actin cross-linking induced by Vibrio cholerae type VI secretion system is associated with intestinal inflammation. Proceedings of the National Academy of Sciences, 107(9), 4365–4370. doi:10.1073/pnas.0915156107

Review Papers

Ho, B. T., Dong, T. G., & Mekalanos, J. J. (2014). A view to a kill: the bacterial type VI secretion system. Cell Host & Microbe, 15(1), 9–21. doi:10.1016/j.chom.2013.11.008

Recommended Readings: Howard Hang, Ph.D. May 17, 2010

Monday Seminar Series

Discovery of Bacterial Virulence Inhibitors

From Plant Extracts

Howard Hang, Ph.D.,


Laboratory of Chemical Biology and Microbial Pathogenesis

May 17, 2010

3:45 p.m.-5:00 p.m.  Welch Hall Level two

Recommended Articles:

 Aiello D;  Williams JD; Majgier-Baranowska H, et al.   2010.  Discovery and Characterization of Inhibitors of Pseudomonas aeruginosa Type III Secretion ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   54(5): 1988-1999   

Rasko DA; Sperandio V.   2010.  Anti-virulence strategies to combat bacteria-mediated disease .  NATURE REVIEWS DRUG DISCOVERY    9 (2): 117-128   

 Veenendaal AKJ;  Sundin C;  Blocker AJ.  2010.  Small-Molecule Type III Secretion System Inhibitors Block Assembly of the Shigella Type III Secreton .    JOURNAL OF BACTERIOLOGY     191(2):563-570   

 Pan NJ, Brady MJ, Leong JM, et al.   2009.  Targeting Type III Secretion in Yersinia pestis.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY     53(2): 385-392  

Raghavan AS, Hang HC .  2009  Seeing small molecules in action with bioorthogonal chemistry .  2009.
 DRUG DISCOVERY TODAY    14(3-4): 178-184    Request from Markus Library.

 Doring O;  Luthje S.   2001.  Inhibition of trans-membrane hexacyanoferrate III reductase activity and proton secretion of maize (Zea mays L.) roots by thenoyltrifluoroacetone .    PROTOPLASMA   217(1-3): 3-8      Request  from Markus Library.

Recommended Readings: Pascale Cossart, Ph.D.

Friday Lecture Series, Ernst A.H. Friedheim Memorial Lecture

The Bacterial Pathogen Listeria monocytogenes: An Amazing Multifaceted Model

Pascale Cossart, Ph.D.

Head, bacteria-cell interactions unit, Director, INSERM unit, Director, Department of cell biology and infection, and Professor, Pasteur Institute

International Research Scholar, Howard Hughes Medical Institute

Friday, January 23, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Bierne, H., and P. Cossart. 2007. Listeria monocytogenes surface proteins: From genome predictions to function. Microbiology and Molecular Biology Reviews. 71 (2):377-397.

Cabanes, D., P. Dehoux, O. Dussurget, L. Frangeul, and P. Cossart. 2002. Surface proteins and the pathogenic potential of Listeria monocytogenes. Trends in Microbiology. 10(5):238-245.

Cossart, P. 2001. Molecular and cellular basis of the infection by Listeria monocytogenes: An overview. International Journal of Medical Microbiology. 291(6-7):401-409.

Cossart, P., and H. Bierne. 2001. The use of host cell machinery in the pathogenesis of Listeria monocytogenes. Current Opinion in Immunology. 13(1):96-103.

Cossart, P., J. Pizarro-Cerda, and M. Lecuit. 2003. Invasion of mammalian cells by Listeria monocytogenes: Functional mimicry to subvert cellular functions. Trends in Cell Biology. 13(1):23-31.

Dussurget, O., Pizarro-Cerda, J., and Cossart, P. 2004. Molecular determinants of Listeria monocytogenes virulence. Annual Review of Microbiology. 58:587-610.

Hamon, M., H. Bierne, and P. Cossart. 2006. Listeria monocytogenes: A multifaceted model. Nature Reviews Microbiology. 4(6):423-434.

Pizarro-Cerda, J., and P. Cossart. 2006. Bacterial adhesion and entry into host cells. Cell. 124(4):715-727.

Pizarro-Cerda, J., and P. Cossart. 2006. Subversion of cellular functions by Listeria monocytogenes. Journal of Pathology. 208(2):215-223.

Recommended Readings: Shu Man Fu, M.D., Ph.D.

Seminars in Clinical Research

Genetics and Pathogenesis of Systemic Lupus: Lessons learned from a Lupus Prone Mouse Model NZM2328

Shu Man Fu, M.D., Ph.D.

Professor of Medicine and Microbiology, Trolinger Professior of Rheumotology

University of Virginia School of Medicine

12 Noon

Wednesday, November 19, 2008

Room 110b, Nurses’ Residence Building

Recommended Articles:

Waters, S. T., M. McDuffie, H. Bagavant, U. S. Deshmukh, F. Gaskin, C. Jiang, K. S. K. Tung, and S. M. Fu. 2004. Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis. Journal of Experimental Medicine. 199(2):255-264.

Rhodes, B., and T. J. Vyse. 2008. The genetics of SLE: An update in the light of genome-wide association studies. Rheumatology. 47(11):1603-1611.
(Request copy from Markus Library)

Kono, D. H., and A. N. Theofilopoulos. 2006.Genetics of SLE in mice. Springer Seminars in Immunopathology. 28(2):83-96.
(Request copy from Markus Library)

Singh, R. R. 2005. SLE: Translating lessons from model systems to human disease. Trends in Immunology. 26(11):572-579.

Bagavant, H., and S. M. Fu. 2005. New insights from murine lupus: Disassociation of autoimmunity and end organ damage and the role of T cells. Current Opinion in Rheumatology. 17(5):523-528.
(Request copy from Markus Library)

Bagavant, H., U. S. Deshmukh, F. Gaskin, and S. M. Fu. 2004. Lupus glomerulonephritis revisited 2004: Autoimmunity and end-organ damage. Scandinavian Journal of Immunology. 60(1):52-63.

Deshmukh, U. S., H. Bagavant, and S. M. Fu. 2006. Role of anti-DNA antibodies in the pathogenesis of lupus nephritis. Autoimmunity Reviews. 5(6):414-418.
(Requestion copy from Markus Library)