Recommended Readings: Andrew Grimson, Ph.D.

Monday Lecture Series

Animal microRNAs: their ancient origin and contemporary targets

Andrew Grimson, Ph.D.

Postdoctoral Fellow

Whitehead Institute for Biomedical Research and Howard Hughes Medical Institute

Monday, March 2, 2009

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Glazov, E. A., S. McWilliam, W. C. Barris, and B. P. Dalrymple. 2008. Origin, evolution, and biological role of miRNA cluster in DLK-DIO3 genomic region in placental mammals. Molecular Biology and Evolution. 25(5):939-948.

Farh, K. K. -H, A. Grimson, C. Jan, B. P. Lewis, W. K. Johnston, L. P. Lim, C. B. Burge, and D. P. Bartel. 2005. Biochemistry: The widespread impact of mammalian microRNAs on mRNA repression and evolution. Science. 310(5755):1817-1821.

Grimson, A., K. K. -H Farh, W. K. Johnston, P. Garrett-Engele, L. P. Lim, and D. P. Bartel. 2007. MicroRNA targeting specificity in mammals: Determinants beyond seed pairing. Molecular Cell. 27(1):91-105.

Grimson, A., M. Srivastava, B. Fahey, B. J. Woodcroft, H. R. Chiang, N. King, B. M. Degnan, D. S. Rokhsar, and D. P. Bartel. 2008. Early origins and evolution of microRNAs and piwi-interacting RNAs in animals. Nature. 455(7217):1193-1197.

Piriyapongsa, J., L. Mariño-Ramírez, and I. K. Jordan. 2007. Origin and evolution of human microRNAs from transposable elements. Genetics. 176(2):1323-1337.

Related Readings: Zhe Li PhD

Special Seminar Series

Cancer Stem Cells and Their Cellular Origins

Monday June 23, 2008

Welch Hall Level 2 Refreshments 3:45 p.m. Lecture 4 p.m.

Recommended Review Article:

Wu, Xiong-Shi.  2008.  Origin of cancer stem cells: the role of self-renewal and differentiation.  Annals of Surgical Oncology.  15(2):407-414

Related Articles:

Gil, J.; Stembalska, A; et al.   2008.  Cancer Stem cells: the theory and perspectives in cancer therapy.  Journal of Applied Genetics.  49(2):193-199

Caers, J.; Van Valckemborgh, E.; et al.   2008.  Unraveling the biology of multiple myeloma disease: cancer stem cells, acquired intracellular changes and interactions with the surrounding micro-environment.  Bulletin du Cancer.  95(3): 301-313.

Li, Zhe; Tognon, C.E.;  et al.  2007.   ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complexCancer Cell.  12(6): 542-558

Li, Zhe; Godinho, F. J.; et al.  2005.  Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nature Genetics  37(6): 1061-4036