Recommended Readings: James Wells, Ph.D., February 5

Friday Lecture Series
Friday, February 5, 2016
3:45 p.m., Carson Family Caspary Auditorium

James M. Wells, Ph.D.
Professor of Pediatrics,
Perinatal Institute Endowed Professor,
Division of Development Biology,
Director for Basic Research,
Division of Endocrinology,
Cincinnati Children’s Hospital Medical Center

Pluripotent Stem Cell-based Models of Human Gastrointestinal Development and Disease

Recommended Reading

Empirical Articles

McCracken, K. W., Catá, E. M., Crawford, C. M., Sinagoga, K. L., Schumacher, M., Rockich, B. E., … & Wells, J. M. (2014). Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature. 516(7531):400-404. doi: 10.1038/nature13863.

Spence, J. R., Mayhew, C. N., Rankin, S. A., Kuhar, M. F., Vallance, J. E., Tolle, K., … & Shroyer, N. F. (2011). Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature, 470(7332), 105-109. doi: 10.1038/nature09691

Watson, C. L., Mahe, M. M., Múnera, J., Howell, J. C., Sundaram, N., Poling, H. M., … & Grabowski, G. (2014). An in vivo model of human small intestine using pluripotent stem cells. Nature Medicine, 20(11), 1310-1314. doi: 10.1038/nm.3737

Review Papers

Sinagoga, K. L., & Wells, J. M. (2015). Generating human intestinal tissues from pluripotent stem cells to study development and disease. The EMBO Journal, 34(9):1149-63. doi: 10.15252/embj.201490686

Wells, J. M., & Spence, J. R. (2014). How to make an intestine. Development, 141(4), 752-760. doi: 10.1242/dev.097386.

Recommended Readings: Madeline Lancaster, Ph.D. Monday, Dec. 11

Special Lecture
The Human Brain in a Dish: Using Cerebral Organoids to Model Development and Disease
Madeline A. Lancaster, Ph.D.
Postdoctoral Fellow
Institute of Molecular Biotechnology
4:00 p.m., Carson Family Auditorium

Recommended Readings

Review Papers

Eiraku, M., & Sasai, Y. (2012). Self-formation of layered neural structures in three-dimensional culture of ES cells. Current Opinion in Neurobiology, 22(5), 768–777. doi:10.1016/j.conb.2012.02.005

Gage, F. H., & Temple, S. (2013). Neural stem cells: generating and regenerating the brain. Neuron, 80(3), 588–601. doi:10.1016/j.neuron.2013.10.037

Han, S. S. W., Williams, L. a, & Eggan, K. C. (2011). Constructing and deconstructing stem cell models of neurological disease. Neuron, 70(4), 626–644. doi:10.1016/j.neuron.2011.05.003

Lui, J. H., Hansen, D. V, & Kriegstein, A. R. (2011). Development and evolution of the human neocortex. Cell, 146(1), 18–36. doi:10.1016/j.cell.2011.06.030

Empirical Articles

Espuny-Camacho, I., Michelsen, K. a, Gall, D., Linaro, D., Hasche, A., Bonnefont, J., … Vanderhaeghen, P. (2013). Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo. Neuron, 77(3), 440–456. doi:10.1016/j.neuron.2012.12.011

Lancaster, M. a, Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., … Knoblich, J. a. (2013). Cerebral organoids model human brain development and microcephaly. Nature, 501(7467), 373–379. doi:10.1038/nature12517

Mariani, J., Simonini, M. V., Palejev, D., Tomasini, L., Coppola, G., Szekely, A. M., … Vaccarino, F. M. (2012). Modeling human cortical development in vitro using induced pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America, 109(31), 12770–12775. doi:10.1073/pnas.1202944109