Recommended Readings: Robert McGinty, M.D., Ph.D., February 18th

Special Lecture,
Wednesday, February 18th, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Robert McGinty, M.D., Ph.D.
Damon Runyun Postdoctoral Fellow,
Dale F. Frey Breakthrough Scientist,
Department of Biochemistry & Molecular Biology,
The Pennsylvania State University

Chemistry, Crystallography and Nucleosome Ubiquitylation

Recommended Readings

Empirical Articles

Kim, J., Kim, J., McGinty, R. K., Nguyen, U. T., Muir, T. W., Allis, C. D., & Roeder, R. G. (2013). The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation. Molecular Cell, 49(6), 1121-1133. doi:10.1016/j.molcel.2013.01.034

McGinty, R. K., Henrici, R. C., & Tan, S. (2014). Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome. Nature, 514(7524), 591-596. doi:10.1038/nature13890

Tang, Z., Chen, W. Y., Shimada, M., Nguyen, U. T., Kim, J., Sun, X. J., … & Roeder, R. G. (2013). SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell, 154(2), 297-310. doi:10.1016/j.cell.2013.06.027

Review Papers

McGinty, R. K., & Tan, S. (In Press). Nucleosome structure and function. Chemical Reviews. doi:10.1021/cr500373h

Recommended Readings: Karim-Jean Armache Ph.D. Monday February 6, 2012

Monday lecture Series

Structural Characterization of Silent Chromatin

Karim-Jean Armache

Postdoctoral Fellow

Department of Molecular Biology

  Harvard Medical School and Massachusetts General Hospital

Monday, February 6,  2012

4 p.m. , Caspary Auditorium.   Refreshments 3:45 p.m.

Recommended Readings:

 Armache KJ; Garlick JD; Canzio D; et al.  2011.  Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 angstrom resolutionSCIENCE.  334(6058):877-982.  DOI:10.1126/science.1210915

Kostrewa D; Zeller ME; Armache KJ; et al.  2009.  RNA polymerase II-TFIIB structure and mechanism of transcription initiation.  NATURE.  462(7271):323-330.  DOI:10.1038/nature08548.

Brueckner F; Armache KJ; Cheung A; et al.  2009. Structure-function studies of the RNA polymerase II elongation complex.  Acta Crystallographica Section D-Biological Crystallography.  65:112-120   DOI:10.1107/S0907444908039875

C ramer, P; Armache KJ; Baumli S; et al.  2008.  Structure of eukaryotic RNA polymerases.  Annual Review of Biophysics.  37:337-352.   DOI:10.1146/annurev.biophys.37.032807.130008

Buchberger JR; Onishi M; Li G;  et al.  2008.  Sir3-nucleosome interactions in spreading of silent chromatin in Saccharomyces cerevisiaeMolecular and Cellular Biology.  28(22):6903-6918.  DOI: 10.1128/MCB.01210-08

Braunstein M; Sobel RE; Allis CD; et al.  1996.  Efficient transcriptional silencing in  Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern.  Molecular and Cellular Biology.  16(8):4349-4356.

Hecht A; Strahl-Bohlsinger S; Grunstein M.  1996.  Spreading of transcriptional repressor SIR3 from telomeric heterochromatin. NATURE.  383(6595):92-96.  DOI:10.1038/383092a0