Recommended Readings: Michael W. Young, Ph.D., Monday October 8, 2018

Monday Lectures

Monday, October 8, 2018  4:00 p.m.

Carson Family Auditorium

Michael W. Young, Ph.D.

Richard and Jeanne Fisher Professor and Head

Laboratory of Genetics

The Rockefeller University

Genes Controlling Sleep and Circadian Rhythms

Recommended Readings:

Science News

Rosemary Braun. A Simple Blood Test Could Tell You the Time Inside Your Body. September 12, 2018. Discover Magazine

Empirical Articles

Young, Michael W. (2018). Time Travels: A 40-Year Journey from Drosophila’s Clock Mutants to Human Circadian Disorders (Nobel Lecture).  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 57 (36): 11532-11539

Top, Deniz; Young, Michael W. (2018). Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 10 (7)

Lin, Changfan; Top, Deniz; Manahan, Craig C.; et al. (2018). Circadian clock activity of cryptochrome relies on tryptophan-mediated photoreduction. PNAS. 115 (15): 3822-3827

Top, Deniz; O’Neil, Jenna L.; Merz, Gregory E.; et al. (2018). CK1/Doubletime activity delays transcription activation in the circadian clock. ELIFE. 7

Patke, Alina; Murphy, Patricia J.; Onat, Onur Emre; et al. (2017). Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder. CELL.  169 (2): 203-215

Rogulja, Dragana; Young, Michael W. (2012). Control of Sleep by Cyclin A and Its Regulator. SCIENCE. 335 (6076): 1617-1621  

Zoltowski, Brian D.; Vaidya, Anand T.; Top, Deniz; et al. (2011). Structure of full-length Drosophila cryptochrome. NATURE. 480 (7377): 396-U156

Review Papers

Wijnen, Herman; Naef, Felix; Boothroyd, Catharine; et al. (2006). Control of daily transcript oscillations in Drosophila by light and the circadian clock. PLOS GENETICS. 2 (3): 326-343

Book Chapter

Axelrod, Sofia; Saez, Lino; Young, Michael W. (2015). Studying Circadian Rhythm and Sleep Using Genetic Screens in Drosophila. METHODS IN ENZIMOLOGY. 551: 3-27  

Crane, Brian R.; Young, Michael W. (2014). Interactive Features of Proteins Composing Eukaryotic Circadian Clocks. ANNUAL REVIEW OF BIOCHEMISTRY. 83: 191-219

Recommended Readings: James Rothman, Ph.D. November 7

Friday Lecture Series
Friday, November 7, 2014
3:45 p.m., Caspary Auditorium

James Rothman, Ph.D.
Fergus F. Wallace Professor Biomedical Sciences and Chemistry,
Professor and Chair,
Department of Cell Biology,
Professor of Chemistry,
Yale School of Medicine

The Regulation of Neurotransmitter Release

Recommended Readings

Empirical Articles

McNew, J. A., Parlati, F., Fukuda, R., Johnston, R. J., Paz, K., Paumet, F., … Rothman, J. E. (2000). Compartmental specificity of cellular membrane fusion encoded in SNARE proteins. Nature, 407(6801), 153–159. doi:10.1038/35025000

Söllner, T., Whiteheart, S. W., Brunner, M., Erdjument-Bromage, H., Geromanos, S., Tempst, P., & Rothman, J. E. (1993). SNAP receptors implicated in vesicle targeting and fusion. Nature, 362(6418), 318–324. doi:10.1038/362318a0

Weber, T., Zemelman, B. V, McNew, J. a, Westermann, B., Gmachl, M., Parlati, F., … Rothman, J. E. (1998). SNAREpins: Minimal Machinery for Membrane Fusion. Cell, 92(6), 759–772. doi:10.1016/S0092-8674(00)81404-X

Wilson, D. W., Wilcox, C. A., Flynn, G. C., Chen, E., Kuang, W. J., Henzel, W. J., … Rothman, J. E. (1989). A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast. Nature, 339(6223), 355–359. doi:10.1038/339355a0

Review Papers

Rothman, J. E. (2014). The principle of membrane fusion in the cell (Nobel lecture). Angewandte Chemie, 2–21. doi:10.1002/anie.201402380

Südhof, T. C., & Rothman, J. E. (2009). Membrane fusion: grappling with SNARE and SM proteins. Science, 323(5913), 474–477. doi:10.1126/science.1161748

Scientific American’s Observations Blog Publishes Reuters Nobel Predictions

Check out Scientific American’s blog site announcement of September 21 for Thomson Reuter’s “short list” of contenders for this year’s Nobel prizes.  The Nobel’s are expected to be announced next month.   Both Jeffrey Friedman and Ralph Steinman are on Reuter’s list for the prize in Physiology or Medicine.    Dr. Friedman was recently announced as one of this year’s co-winners of the Lasker Award.

AIDS pioneers and HPV cancer researcher win Nobel Prize for medicine or physiology

On Monday, October 6, 2008, two French scientists who discovered the AIDS virus and a German scientist who found the virus the causes cervical cancer were awarded the Nobel prize for medicine or physiology.  A brief podcast and video describe these awards.

Luc Montagnier, director of the World Foundation for AIDS Research and Prevention, and Francoise Barre-Sinoussi of the Institut Pasteur won half of the prize for discovering the AIDS virus which has killed millions of people. 

Harald zur Hausen of the University of Duesseldorf shared the other half of the prize for work that ran counter to the current dogma related to the cause of cervical cancer. 

The French scientists identified virus production in lymphocytes from early-stage, acquired immunodeficiency patients and from blood from patients with late stages of the disease.  This virus became known as human immunodeficiency virus (HIV).  These findings led to the current understanding of the biology of the disease and antiretroviral treatment.

Harald zur Hausen was awarded the other half of the Nobel prize for work which proved that oncogenic human papilloma virus (HPV) casued cervical cancer, the second most common cancer in women.  This discovery led to understanding the basis for HPV infection and HPV-induced cancers and the subsequent development of prophylactic vaccines against HPV. 

Montagnier, upon receiving the honor, said that a treatment for AIDS could be possible in the future with a therapeutic, rather than a preventive vaccine.  A therapeutic vaccine prevents disease from fluorishing once it has taken hold.