Recommended Readings: Susan Lindquist, Ph.D. October 17

Friday Lecture Series
Friday, October 17, 2014
3:45 p.m., Caspary Auditorium

Susan Lindquist, Ph.D.
Professor of Biology,
Massachussetts Institute of Technology
Whitehead Institute for Biomedical Research
Howard Hughes Medical Institute

From Yeast to Patient Neurons and Back Again: Powerful Discovery Platforms Combatting Neurodegenerative Disease

Recommended Readings

Empirical Articles

Chung, C. Y., Khurana, V., Auluck, P. K., Tardiff, D. F., Mazzulli, J. R., Soldner, F., … Lindquist, S. (2013). Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science, 342(6161), 983–987. doi:10.1126/science.1245296

Tardiff, D. F., Jui, N. T., Khurana, V., Tambe, M. A, Thompson, M. L., Chung, C. Y., … Lindquist, S. (2013). Yeast reveal a “druggable” Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science, 342(6161), 979–983. doi:10.1126/science.1245321

Treusch, S., Hamamichi, S., Goodman, J. L., Matlack, K. E. S., Chung, C. Y., Baru, V., … Lindquist, S. (2011). Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer’s disease risk factors in yeast. Science, 334(6060), 1241–1245. doi:10.1126/science.1213210

Review Papers

Khurana, V., & Lindquist, S. (2010). Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker’s yeast? Nature Reviews Neuroscience, 11(6), 436–449. doi:10.1038/nrn2809

Tardiff, D. F., Khurana, V., Chung, C. Y., & Lindquist, S. (2014). From yeast to patient neurons and back again: A powerful new discovery platform. Movement Disorders, 29(10), 1231–1240. doi:10.1002/mds.25989

Recommended Readings: Gizem Donmez, PhD Sept 27, 2010

Monday Lecture Series

The Role of SIRT1 in Neurodegenerative Diseases

Gizem Donmez, Ph.D.,

Post Doctoral Fellow 

Glenn Laboratory for the Science of Aging, Department of Biology

Massachusetts Institute of Technology

September 27, 2010

4:00 p.m.  Welch Hall Level Two

Recommended Review Article:

Haigis MC, Sinclair DA.  2010.   Mammalian Sirtuins: Biological Insights and Disease Relevance.

Recommended Readings:

Donmez G, Wang D, Cohen DE, et al.  2010. SIRT1 Suppresses beta-Amyloid Production by Activating the alpha-Secretase Gene ADAM10.    CELL    142 ( 2):320-332   

Albani D, Polito L, Forloni G. 2010.  Sirtuins as Novel Targets for Alzheimer’s Disease and Other Neurodegenerative Disorders: Experimental and Genetic Evidence.  JOURNAL OF ALZHEIMERS DISEASE 19(1): 11-26    PLEASE CONTACT MARKUS LIBRARY FOR A COPY OF THIS ARTICLE.

Gao J, Wang WY, Mao YW, et al.   2010.  A novel pathway regulates memory and plasticity via SIRT1 and miR-134NATURE    466( 7310): 1105-U120   

Michan S, Li Y, Chou MMH, et al.   2010.  SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity.   JOURNAL OF NEUROSCIENCE    30(29): 9695-9707   

Tang BL, Chua CEL.  2010.  Is systemic activation of Sirt1 beneficial for ageing-associated metabolic disorders?   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS    391(1): 6-10

Tang BL.  2009.  Sirt1’s Complex Roles in Neuroprotection.   CELLULAR AND MOLECULAR NEUROBIOLOGY    29(8):1093-1103