Recommended Readings: Marc Tessier-Lavigne, Ph.D., April 6

Monday Lecture Series
Monday, April 6, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Marc Tessier-Lavigne, Ph.D.,
Carson Family Professor and Head,
Laboratory of Brain Development and Repair,
The Rockefeller University

Sculpting Neuronal Connections: The Logic and Mechanisms of Axon Growth and Pruning

Recommended Readings

Empirical Articles

Leyva-Díaz, E., del Toro, D., Menal, M. J., Cambray, S., Susín, R., Tessier-Lavigne, M., … & López-Bendito, G. (2014). FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons. Current Biology, 24(5), 494-508. doi:10.1016/j.cub.2014.01.042

Mire, E., Mezzera, C., Leyva-Díaz, E., Paternain, A. V., Squarzoni, P., Bluy, L., … & López-Bendito, G. (2012). Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth. Nature Neuroscience, 15(8), 1134-1143. doi:10.1038/nn.3160

Romi, E., Gokhman, I., Wong, E., Antonovsky, N., Ludwig, A., Sagi, I., … & Yaron, A. (2014). ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A. Nature communications, 5. doi:10.1038/ncomms5058

Xu, K., Wu, Z., Renier, N., Antipenko, A., Tzvetkova-Robev, D., Xu, Y., … & Nikolov, D. B. (2014). Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. Science, 344(6189), 1275-1279. doi:10.1126/science.1255149

Review Papers

Kolodkin, A. L., & Tessier-Lavigne, M. (2011). Mechanisms and molecules of neuronal wiring: a primer. Cold Spring Harbor Perspectives in Biology, 3(6), a001727. doi:10.1101/cshperspect.a001727

Brain Protein netrin-1 New Clue to Alzheimers

A study from the Buck Institute for Age Research offers a revolutionary new model for Alzheimer’s disease. They have discovered a naturally occurring protein that provides a new therapeutic target, and suggests that Alzheimers is  a disorder involving an imbalance in signaling between neurons.  Read the complete report of research in Cell Death and Differentiation.