Recommended Readings: Jos Jonkers, Ph.D., March 20

Friday Lecture Series
Friday, March 20, 2015
3:45 p.m., Caspary Auditorium

Jos Jonkers, Ph.D.
Head, Division of Molecular Pathology,
Netherlands Cancer Institute

Unraveling Therapy Response and Resistance in Mouse Models of Human Breast Cancer

Recommended Readings

Empirical Articles

Bouwman, P., Aly, A., Escandell, J. M., Pieterse, M., Bartkova, J., van der Gulden, H., … & Jonkers, J. (2010). 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nature Structural & Molecular Biology, 17(6), 688-695. doi:10.1038/nsmb.1831.

Jonkers, J., Meuwissen, R., van der Gulden, H., Peterse, H., van der Valk, M., & Berns, A. (2001). Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nature Genetics, 29(4), 418-425. doi:10.1038/ng747

Liu, X., Holstege, H., van der Gulden, H., Treur-Mulder, M., Zevenhoven, J., Velds, A., … & Jonkers, J. (2007). Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proceedings of the National Academy of Sciences, 104(29), 12111-12116. doi:10.1073/pnas.0702969104

Rottenberg, S., Jaspers, J. E., Kersbergen, A., van der Burg, E., Nygren, A. O., Zander, S. A., … & Jonkers, J. (2008). High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proceedings of the National Academy of Sciences, 105(44), 17079-17084. doi:10.1073/pnas.0806092105

Review Papers

Bouwman, P., & Jonkers, J. (2014). Molecular Pathways: How can BRCA-mutated tumors become resistant to PARP inhibitors?. Clinical Cancer Research, 20(3), 540-547. doi:10.1158/1078-0432.CCR-13-0225

Klarenbeek, S., van Miltenburg, M. H., & Jonkers, J. (2013). Genetically engineered mouse models of PI3K signaling in breast cancer. Molecular Oncology, 7(2), 146-164. doi:10.1016/j.molonc.2013.02.003

Recommended Readings: Sohail Tavazoie, Ph.D. October 6

Monday Lecture Series
Monday, October 6, 2014
3:45 p.m., Caspary Auditorium

Sohail Tavazoie, Ph.D.
Leon Hess Assistant Professor and Head,
Elizabeth and Vincent Meyer Laboratory of Systems Cancer Biology,
The Rockefeller University
Senior Attending Physician,
The Rockefeller University Hospital

Molecular Control of Cancer Metastasis

Recommended Readings

Empirical Articles

Pencheva, N., Tran, H., Buss, C., Huh, D., Drobnjak, M., Busam, K., & Tavazoie, S. F. (2012). Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis. Cell, 151(5), 1068–1082. doi:10.1016/j.cell.2012.10.028

Png, K. J., Halberg, N., Yoshida, M., & Tavazoie, S. F. (2012). A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature, 481(7380), 190–194. doi:10.1038/nature10661

Png, K. J., Yoshida, M., Zhang, X. H.-F., Shu, W., Lee, H., Rimner, A., … Tavazoie, S. F. (2011). MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer. Genes & Development, 25(3), 226–231. doi:10.1101/gad.1974211

Tavazoie, S. F., Alarcón, C., Oskarsson, T., Padua, D., Wang, Q., Bos, P. D., … Massagué, J. (2008). Endogenous human microRNAs that suppress breast cancer metastasis. Nature, 451(7175), 147–52. doi:10.1038/nature06487

Review Papers

Pencheva, N., & Tavazoie, S. F. (2013). Control of metastatic progression by microRNA regulatory networks. Nature Cell Biology, 15(6), 546–54. doi:10.1038/ncb2769

Recommended Readings: Mark M. Davis, Ph.D. April 25

Friday Lecture Series
Friday, April 25, 2014
3:45 p.m., Caspary Auditorium

Mark M. Davis, Ph.D.
Burt and Marion Avery Family Professor of Immunology
Director, Stanford Institute for Immunity, Transplantation and Infection
Member, Bio-X and Stanford Cancer Institute
Stanford University

Reinventing Human Immunology

Recommended Readings:

Davis, M. M. (2008). A prescription for human immunology. Immunity, 29(6), 835–838. doi:10.1016/j.immuni.2008.12.003

Davis, M. M. (2012). Immunology taught by humans. Science Translational Medicine, 4(117), 117fs2. doi:10.1126/scitranslmed.3003385

Kidd, B. a, Peters, L. a, Schadt, E. E., & Dudley, J. T. (2014). Unifying immunology with informatics and multiscale biology. Nature Immunology, 15(2), 118–127. doi:10.1038/ni.2787

Maecker, H. T., McCoy, J. P., & Nussenblatt, R. (2012). Standardizing immunophenotyping for the Human Immunology Project. Nature Reviews Immunology, 12(3), 191–200. doi:10.1038/nri3158

Su, L. F., Han, A., McGuire, H. M., Furman, D., Newell, E. W., & Davis, M. M. (2014). The Promised Land of Human Immunology. Cold Spring Harbor Symposia on Quantitative Biology. doi:10.1101/sqb.2013.78.022905