Recommended Readings: Mary Jeanne Kreek, M.D., May 2

Monday Lecture Series
Monday, May 2, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Mary Jeanne Kreek, M.D.
Senior Attending Physician,
The Rockefeller University Hospital
Patrick E. and Beatrice M. Haggerty Professor and Head,
Laboratory of the Biology of Addictive Diseases,
The Rockefeller University

50th Anniversary of First Research Paper on Methadone Maintenance Treatment: Update on Molecular, Neurobiological, Behavioral, and Genetic Research

Recommended Readings:

Bond, C., LaForge, K. S., Tian, M., Melia, D., Zhang, S., Borg, L., … & Tischfield, J. A. (1998). Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: possible implications for opiate addiction. Proceedings of the National Academy of Sciences, 95(16), 9608-9613.

Butelman, E. R., Yuferov, V., & Kreek, M. J. (2012). κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction. Trends in Neurosciences, 35(10), 587-596. doi:10.1016/j.tins.2012.05.005.

Dole, V. P., Nyswander, M. E., & Kreek, M. J. (1966). Narcotic blockade. Archives of Internal Medicine, 118(4), 304-309. doi:10.1001/archinte.1966.00290160004002

Kreek, M. J., Nielsen, D. A., Butelman, E. R., & LaForge, K. S. (2005). Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nature Neuroscience, 8(11), 1450-1457. doi:10.1038/nn1583

Reed, B., Butelman, E. R., Yuferov, V., Randesi, M., & Kreek, M. J. (2014). Genetics of opiate addiction. Current Psychiatry Reports, 16(11), 1-12. doi:10.1007/s11920-014-0504-6.

Recommended Readings: Victor Ambros, Ph.D.

Friday Lecture Series


microRNA Pathways in Animal Development

Joshua Lederberg Distinguished Lectureship in Molecular Genetics


Victor Ambros, Ph.D., Silverman Professor of Natural Science, co-director,

RNA Therapeutics Institute,

University of Massachusetts Medical School

February 3, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings:

Ambros, V. 2010. MicroRNAs: Genetically sensitized worms reveal new secrets. Current Biology 20, (14): R598-R600

Hammell, C. M., X. Karp, and V. Ambros. 2009. A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America 106, (44): 18668-18673

Hammell, C. M., I. Lubin, P. R. Boag, T. K. Blackwell, and V. Ambros. 2009. Nhl-2 modulates MicroRNA activity in caenorhabditis elegans. Cell 136, (5): 926-938

Hammell, M., D. Long, L. Zhang, A. Lee, C. S. Carmack, M. Han, Y. Ding, and V. Ambros. 2008. mirWIP: MicroRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts. Nature Methods 5, (9): 813-819

Miska, E. A., E. Alvarez-Saavedra, A. L. Abbott, N. C. Lau, A. B. Hellman, S. M. McGonagle, D. P. Bartel, V. R. Ambros, and H. R. Horvitz. 2007. Most caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genetics 3, (12): 2395-2403

Sokol, N. S., P. Xu, Y. -N Jan, and V. Ambros. 2008. Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis. Genes and Development 22, (12): 1591-1596